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Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta

1
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China
2
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
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Author to whom correspondence should be addressed.
Mar. Drugs 2014, 12(7), 3982-3993; https://doi.org/10.3390/md12073982
Received: 28 March 2014 / Revised: 28 May 2014 / Accepted: 3 June 2014 / Published: 30 June 2014
Two new indole alkaloids, hainanerectamines A (1) and B (2), and one new β-carboline alkaloids, hainanerectamines C (4), along with five known related alkaloids (3, 58), have been isolated from the Hainan marine sponge Hyrtios erecta. The structures of new compounds 1, 2 and 4 were determined by detailed analysis of their 1D and 2D NMR spectra and by comparison of their spectroscopic data with those of related model compounds. Compounds 24 exhibited moderate inhibitory activity against Aurora A, a member of serine/threonine kinase family involving in the regulation of cell division and a new target in cancer treatment, with IC50 values of 24.5, 13.6, and 18.6 μg/mL, respectively. View Full-Text
Keywords: sponge; Hyrtios erecta; Thorectidae; hainanerectamines; indole; β-carboline; Aurora A sponge; Hyrtios erecta; Thorectidae; hainanerectamines; indole; β-carboline; Aurora A
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He, W.-F.; Xue, D.-Q.; Yao, L.-G.; Li, J.-Y.; Li, J.; Guo, Y.-W. Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta. Mar. Drugs 2014, 12, 3982-3993.

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