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Open AccessCommunication
Mar. Drugs 2014, 12(4), 2144-2155;

Cladieunicellins M–Q, New Eunicellins from Cladiella sp.

Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 3 March 2014 / Revised: 20 March 2014 / Accepted: 27 March 2014 / Published: 8 April 2014
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Five new 7α-hydroxyeunicellin-based diterpenoids, designated as cladieunicellins M–Q (15), were isolated from a Formosan octocoral Cladiella sp. The structures of 15 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 15 against the human leukemia Molt 4 and HL 60 is also described. Among them, compounds 1, 3 and 5 exhibited moderate cytotoxicity toward Molt 4 cells with IC50 values 16.43, 14.17 and 15.55 μM, respectively. Preliminary SAR (structure activity relationship) information was obtained from these compounds and their analogues. View Full-Text
Keywords: eunicellin; Cladiella; cladieunicellin; cytotoxicity eunicellin; Cladiella; cladieunicellin; cytotoxicity

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Chen, T.-H.; Chen, W.-F.; Wen, Z.-H.; Lu, M.-C.; Wang, W.-H.; Li, J.-J.; Wu, Y.-C.; Sung, P.-J. Cladieunicellins M–Q, New Eunicellins from Cladiella sp.. Mar. Drugs 2014, 12, 2144-2155.

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