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Open AccessReview

Marine Nucleosides: Structure, Bioactivity, Synthesis and Biosynthesis

Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK
College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China
School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China
Life Science & Technology School, Lingnan Normal University, Zhanjiang 52048, China
Author to whom correspondence should be addressed.
Mar. Drugs 2014, 12(12), 5817-5838;
Received: 4 August 2014 / Revised: 20 November 2014 / Accepted: 21 November 2014 / Published: 2 December 2014
PDF [946 KB, uploaded 24 February 2015]


Nucleosides are glycosylamines that structurally form part of nucleotide molecules, the building block of DNA and RNA. Both nucleosides and nucleotides are vital components of all living cells and involved in several key biological processes. Some of these nucleosides have been obtained from a variety of marine resources. Because of the biological importance of these compounds, this review covers 68 marine originated nucleosides and their synthetic analogs published up to June 2014. The review will focus on the structures, bioactivities, synthesis and biosynthetic processes of these compounds. View Full-Text
Keywords: biological activity; biosynthetic pathway; marine organism; nucleoside; synthesis biological activity; biosynthetic pathway; marine organism; nucleoside; synthesis

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Huang, R.-M.; Chen, Y.-N.; Zeng, Z.; Gao, C.-H.; Su, X.; Peng, Y. Marine Nucleosides: Structure, Bioactivity, Synthesis and Biosynthesis. Mar. Drugs 2014, 12, 5817-5838.

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