Anti HSV-1 Activity of Halistanol Sulfate and Halistanol Sulfate C Isolated from Brazilian Marine Sponge Petromica citrina (Demospongiae)
Abstract
:1. Introduction
2. Results and Discussion
2.1. Bioguided Fractionation of the n-Butanol Fraction of P. citrina
3. Experimental Section
3.1. General Experimental Procedures
3.2. Sponge Collection
3.3. Extraction and Isolation of Compounds 1 and 2
3.4. Anti-HSV-1 Activity
3.4.1. Virus and Cell Line
3.4.2. Cytotoxicity Assay
4. Conclusions
Acknowledgments
Abbreviations
CMC | Carboxymethylcellulose |
COSY | Correlation Spectroscopy |
ESI | Electrospray ionization |
HMBC | Heteronuclear Multiple Bond Correlation |
HSQC | Heteronuclear Single Quantum Correlation |
HSV | Herpes Simplex Virus |
MEM | Minimal Essential Medium |
NMR | Nuclear Magnetic Resonance |
PFU | Plaque Forming Units |
TSH | Halistanol-Enriched Fraction |
Conflict of Interest
References
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Da Rosa Guimarães, T.; Quiroz, C.G.; Rigotto, C.; De Oliveira, S.Q.; De Almeida, M.T.R.; Bianco, É.M.; Moritz, M.I.G.; Carraro, J.L.; Palermo, J.A.; Cabrera, G.; et al. Anti HSV-1 Activity of Halistanol Sulfate and Halistanol Sulfate C Isolated from Brazilian Marine Sponge Petromica citrina (Demospongiae). Mar. Drugs 2013, 11, 4176-4192. https://doi.org/10.3390/md11114176
Da Rosa Guimarães T, Quiroz CG, Rigotto C, De Oliveira SQ, De Almeida MTR, Bianco ÉM, Moritz MIG, Carraro JL, Palermo JA, Cabrera G, et al. Anti HSV-1 Activity of Halistanol Sulfate and Halistanol Sulfate C Isolated from Brazilian Marine Sponge Petromica citrina (Demospongiae). Marine Drugs. 2013; 11(11):4176-4192. https://doi.org/10.3390/md11114176
Chicago/Turabian StyleDa Rosa Guimarães, Tatiana, Carlos Guillermo Quiroz, Caroline Rigotto, Simone Quintana De Oliveira, Maria Tereza Rojo De Almeida, Éverson Miguel Bianco, Maria Izabel Goulart Moritz, João Luís Carraro, Jorge Alejandro Palermo, Gabriela Cabrera, and et al. 2013. "Anti HSV-1 Activity of Halistanol Sulfate and Halistanol Sulfate C Isolated from Brazilian Marine Sponge Petromica citrina (Demospongiae)" Marine Drugs 11, no. 11: 4176-4192. https://doi.org/10.3390/md11114176