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Mar. Drugs 2012, 10(2), 427-438;

Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea)

Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan
Department of Nutrition, HungKuang University, Taichung 433, Taiwan
Department of Orthopedics, Taichung Veterans General Hospital, Taichung 407, Taiwan
Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources and Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Authors to whom correspondence should be addressed.
Received: 8 December 2011 / Revised: 6 February 2012 / Accepted: 9 February 2012 / Published: 15 February 2012
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A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to display a significant inhibitory effect on the release of elastase by human neutrophils. View Full-Text
Keywords: menelloide; germacrane; Menella; lobocrassin; cembrane; Lobophytum; elastase menelloide; germacrane; Menella; lobocrassin; cembrane; Lobophytum; elastase

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Lee, C.-H.; Kao, C.-Y.; Kao, S.-Y.; Chang, C.-H.; Su, J.-H.; Hwang, T.-L.; Kuo, Y.-H.; Wen, Z.-H.; Sung, P.-J. Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea). Mar. Drugs 2012, 10, 427-438.

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