13-Epi-9-deacetoxyxenicin, a Cytotoxic Diterpene from the Soft Coral Asterospicularia laurae (Alcyonacea)
Abstract
:Introduction
Results and Discussion
Conclusions
Experimental
General
Animal material
Extraction and Purification
Spectral Data
Compound | 1 | 2 | 3 | |||
---|---|---|---|---|---|---|
Carbon | δ1H, mult., J(Hz) | δ13C | δ1H, mult., J(Hz) | δ13C | δ1H, mult., J(Hz) | δ13C |
1 | 5.87, d, 1.5 | 91.4 | 5.86, d, 1.8 | 91.7 | 6.08, d, 2.4 | 92.4 |
3 | 6.49, d, 1.8 | 141.7 | 6.49, d, 1.5 | 141.9 | 6.45, brs | 142.0 |
4 | 113.6 | 113.5 | 111.5 | |||
4a | 2.2, m | 37.1 | 2.33, brd, 13.8 | 36.6 | 2.44, m | 32.1 |
5 | 1.55, m; 1.95, m | 30.3 | 2.05, m; 1.97, m | 30.5 | 1.78, m; 2.32, m | 30.5 |
6 | 2.0 – 2.2, m, 2H | 39.6 | 2.2, m | 39.5 | 2.22, m; 2.38, m | 25.6 |
7 | 135.5 | 133.0 | 145.5 | |||
8 | 5.37, brt, 7.9 | 124.4 | 5.24, brd, 9.3 | 131.0 | 4.41, dd, 5.0, 10.4 | 90.0 |
9 | 2.25, m; 2.45, m | 24.9 | 4.72, brdd, 7.2, 6.0 | 67.7 | 2.03, m; 1.64, m | 26.5 |
10 | 2.15 – 2.25, m | 35.4 | 2.3, m; 2.6, m | 46.3 | 2.12–2.24, m | 30.7 |
11 | 151.3 | 147.2 | 146.6 | |||
11a | 1.95, m | 48.9 | 1.85, brs | 49.4 | 2.70, brt, 1.5 | 39.3 |
12 | 5.32, d, 6.6 | 74.9 | 5.31, d, 6.8 | 74.9 | 5.29, d, 7.5 | 74.8 |
13 | 5.68, dd, 6.6, 9.3 | 70.0 | 5.69, dd, 6.8, 9.3 | 69.9 | 5.59, dd, 7.5, 9.3 | 69.6 |
14 | 5.14, dsept, 9.3, 1.2 | 119.5 | 5.13, brd, 9.3 | 119.5 | 5.10, brd, 9.3 | 119.6 |
15 | 140.0 | 140.1 | 140.1 | |||
16 | 1.74, d, 1.2 | 25.8 | 1.74, brs | 25.8 | 1.73, brs | 25.9 |
17 | 1.75, d, 1.2 | 18.5 | 1.74, brs | 18.6 | 1.75, brs | 18.6 |
18 | 1.65, d, 0.8 | 16.7 | 1.64, brs | 17.7 | 5.34, brs; 5.41, brs | 119.0 |
19 | 4.78, d, 1.2; 4.86, brs | 112.9 | 4.56, brs; 4.84, brs | 115.1 | 4.79, brs, 4.87, brs | 112.1 |
1-OAc | 2.03, s | 20.9 | 2.02, s | 20.9 | 2.05, s | 21.0 |
169.5 | 169.5 | 169.4 | ||||
12-OAc | *2.02, s | 21.1 | 2.01, s | 21.1 | 2.01, s | 21.1 |
169.8 | 169.8 | 169.8 | ||||
13-OAc | *2.00, s | 21.1 | 2.00, s | 21.2 | 1.95, s | 21.0 |
169.8 | 170.0 | 169.9 | ||||
8-OOH | 8.17, brs |
Acknowledgements
- Sample Availability: Samples are available from the authors.
References
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Bowden, B.F.; Cusack, B.J.; Dangel, A. 13-Epi-9-deacetoxyxenicin, a Cytotoxic Diterpene from the Soft Coral Asterospicularia laurae (Alcyonacea). Mar. Drugs 2003, 1, 18-26. https://doi.org/10.3390/md101018
Bowden BF, Cusack BJ, Dangel A. 13-Epi-9-deacetoxyxenicin, a Cytotoxic Diterpene from the Soft Coral Asterospicularia laurae (Alcyonacea). Marine Drugs. 2003; 1(1):18-26. https://doi.org/10.3390/md101018
Chicago/Turabian StyleBowden, Bruce F., Bernard J. Cusack, and Alissa Dangel. 2003. "13-Epi-9-deacetoxyxenicin, a Cytotoxic Diterpene from the Soft Coral Asterospicularia laurae (Alcyonacea)" Marine Drugs 1, no. 1: 18-26. https://doi.org/10.3390/md101018