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Drug Resistance in Mycobacterium tuberculosis

Rabia Johnson
Elizabeth M. Streicher
Gail E. Louw
Robin M. Warren
Paul D. van Helden
Thomas C. Victor
DST/NRF Centre of Excellence in Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Science, Faculty of Health Science, Tygerberg, Stellenbosch University, Stellenbosch 7615, South Africa
Author to whom correspondence should be addressed.
Equal contributions as principal authors.
Curr. Issues Mol. Biol. 2006, 8(2), 97-112;
Submission received: 7 March 2006 / Revised: 5 May 2006 / Accepted: 7 June 2006 / Published: 2 August 2006


Anti-tuberculosis drugs are a two-edged sword. While they destroy pathogenic M. tuberculosis they also select for drug resistant bacteria against which those drugs are then ineffective. Global surveillance has shown that drug resistant Tuberculosis is widespread and is now a threat to tuberculosis control programs in many countries. Application of molecular methods during the last decade has greatly changed our understanding of drug resistance in tuberculosis. Application of molecular epidemiological methods was also central to the description of outbreaks of drug resistance in Tuberculosis. This review describes recommendations for Tuberculosis treatment according to the WHO guidelines, the drug resistance problem in the world, mechanisms of resistance to first line and second line drugs and applications of molecular methods to detect resistance causing gene mutations. It is envisaged that molecular techniques may be important adjuncts to traditional culture based procedures to rapidly screen for drug resistance. Prospective analysis and intervention to prevent transmission may be particularly helpful in areas with ongoing transmission of drug resistant strains as recent mathematical modeling indicate that the burden of MDR-TB cannot be contained in the absence of specific efforts to limit transmission.

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MDPI and ACS Style

Johnson, R.; Streicher, E.M.; Louw, G.E.; Warren, R.M.; van Helden, P.D.; Victor, T.C. Drug Resistance in Mycobacterium tuberculosis. Curr. Issues Mol. Biol. 2006, 8, 97-112.

AMA Style

Johnson R, Streicher EM, Louw GE, Warren RM, van Helden PD, Victor TC. Drug Resistance in Mycobacterium tuberculosis. Current Issues in Molecular Biology. 2006; 8(2):97-112.

Chicago/Turabian Style

Johnson, Rabia, Elizabeth M. Streicher, Gail E. Louw, Robin M. Warren, Paul D. van Helden, and Thomas C. Victor. 2006. "Drug Resistance in Mycobacterium tuberculosis" Current Issues in Molecular Biology 8, no. 2: 97-112.

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