A Tissue Engineered 3D Model of Cancer Cell Invasion for Human Head and Neck Squamous-Cell Carcinoma
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Oral Mucosa Model | Tumor Formation | ||
---|---|---|---|
Tumor spots | Regularly formed epithelium | No signs of malignancy or tumor formation | |
Tumor spheroids | Regularly formed epithelium | Tumor cells located on top of stratum corneum | |
Single tumor cells | 1:50 | Continuously formed stratum corneum, cells in the basal layers appeared irregular with nuclear pleomorphism and differences in size | Formation of tumor cell clusters; no invasion into lamina propria |
1:33 | Disturbed epithelial architecture | Invasive tumor growth | |
1:25 | No regular epithelial structure, atypical cornification | Invasive tumor growth | |
1:10 | No regular epithelial structure, atypical cornification | Invasive tumor growth |
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Stöth, M.; Mineif, A.T.; Sauer, F.; Meyer, T.J.; Mueller-Diesing, F.; Haug, L.; Scherzad, A.; Steinke, M.; Rossi, A.; Hackenberg, S. A Tissue Engineered 3D Model of Cancer Cell Invasion for Human Head and Neck Squamous-Cell Carcinoma. Curr. Issues Mol. Biol. 2024, 46, 4049-4062. https://doi.org/10.3390/cimb46050250
Stöth M, Mineif AT, Sauer F, Meyer TJ, Mueller-Diesing F, Haug L, Scherzad A, Steinke M, Rossi A, Hackenberg S. A Tissue Engineered 3D Model of Cancer Cell Invasion for Human Head and Neck Squamous-Cell Carcinoma. Current Issues in Molecular Biology. 2024; 46(5):4049-4062. https://doi.org/10.3390/cimb46050250
Chicago/Turabian StyleStöth, Manuel, Anna Teresa Mineif, Fabian Sauer, Till Jasper Meyer, Flurin Mueller-Diesing, Lukas Haug, Agmal Scherzad, Maria Steinke, Angela Rossi, and Stephan Hackenberg. 2024. "A Tissue Engineered 3D Model of Cancer Cell Invasion for Human Head and Neck Squamous-Cell Carcinoma" Current Issues in Molecular Biology 46, no. 5: 4049-4062. https://doi.org/10.3390/cimb46050250
APA StyleStöth, M., Mineif, A. T., Sauer, F., Meyer, T. J., Mueller-Diesing, F., Haug, L., Scherzad, A., Steinke, M., Rossi, A., & Hackenberg, S. (2024). A Tissue Engineered 3D Model of Cancer Cell Invasion for Human Head and Neck Squamous-Cell Carcinoma. Current Issues in Molecular Biology, 46(5), 4049-4062. https://doi.org/10.3390/cimb46050250