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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Epigenomics: Genome-Wide Study of Methylation Phenomena

by
K. L. Novik
1,*,
I. Nimmrich
2,
B. Genc
2,
S. Maier
2,
C. Piepenbrock
2,
A. Olek
2 and
S. Beck
1
1
Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK
2
Epigenomics AG, Kastanienallee 24, 10435 Berlin, Germany
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2002, 4(4), 111-128; https://doi.org/10.21775/cimb.004.111
Submission received: 9 May 2002 / Revised: 11 July 2002 / Accepted: 12 September 2002 / Published: 16 November 2002
Versions Notes

Abstract

Epigenetics is one of the key areas of future research that can elucidate how genomes work. It combines genetics and the environment to address complex biological systems such as the plasticity of our genome. While all nucleated human cells carry the same genome, they express different genes at different times. Much of this is governed by epigenetic changes resulting in differential methylation of our genome - or different epigenomes. Individual studies over the past decades have already established the involvement of DNA methylation in imprinting, gene regulation, chromatin structure, genome stability and disease, especially cancer. Now, in the wake of the Human Genome Project (HGP), epigenetic phenomena can be studied genome-wide and are giving rise to a new field, epigenomics. Here, we review the current and future potential of this field and introduce the pilot study towards the Human Epigenome Project (HEP).

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MDPI and ACS Style

Novik, K.L.; Nimmrich, I.; Genc, B.; Maier, S.; Piepenbrock, C.; Olek, A.; Beck, S. Epigenomics: Genome-Wide Study of Methylation Phenomena. Curr. Issues Mol. Biol. 2002, 4, 111-128. https://doi.org/10.21775/cimb.004.111

AMA Style

Novik KL, Nimmrich I, Genc B, Maier S, Piepenbrock C, Olek A, Beck S. Epigenomics: Genome-Wide Study of Methylation Phenomena. Current Issues in Molecular Biology. 2002; 4(4):111-128. https://doi.org/10.21775/cimb.004.111

Chicago/Turabian Style

Novik, K. L., I. Nimmrich, B. Genc, S. Maier, C. Piepenbrock, A. Olek, and S. Beck. 2002. "Epigenomics: Genome-Wide Study of Methylation Phenomena" Current Issues in Molecular Biology 4, no. 4: 111-128. https://doi.org/10.21775/cimb.004.111

APA Style

Novik, K. L., Nimmrich, I., Genc, B., Maier, S., Piepenbrock, C., Olek, A., & Beck, S. (2002). Epigenomics: Genome-Wide Study of Methylation Phenomena. Current Issues in Molecular Biology, 4(4), 111-128. https://doi.org/10.21775/cimb.004.111

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