Next Article in Journal
Identification and Isolation of an Azoreductase from Enterococcus faecium
Previous Article in Journal
One-Step DNA Fragment Assembly and Circularization for Gene Cloning
 
 
Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Bacterial Secretion Systems with an Emphasis on the Chlamydial Type III Secretion System

by
Delphine Sylvie Anne Beeckman
* and
Daisy C.G. Vanrompay
Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, BE-9000 Ghent, Belgium
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2010, 12(1), 17-42; https://doi.org/10.21775/cimb.012.017
Submission received: 3 March 2009 / Revised: 10 March 2009 / Accepted: 9 May 2009 / Published: 16 July 2009

Abstract

Numerous bacterial proteins exert their function outside the prokaryotic cell. To this end, both Gram-negative and Gram-positive bacteria have evolved specialized mechanisms to transport their proteins to the bacterial supernatant or host cell cytoplasm, so called secretion systems. These different strategies will be briefly discussed, followed by an in depth description of the Type III secretion system, an efficient molecular syringe assisting Gram-negative bacteria in entrance, growth and survival in eukaryotic host cells. Topics addressed include classification and role of multiple Type III secretion systems, the mechanism of protein translocation into the host cell as well as substrate recognition and chaperoning. Chlamydiales have also been found to encode a Type III secretion system and associated effector proteins. In contrast to the genetic organization in other bacteria, the encoding genes are scattered throughout the genome. To date, no structural information is available on the chlamydial Type III secretion system. We therefore propose a model of the chlamydial Type III secretion system and summarize current knowledge on the role of Type III secretion in the different stages of the chlamydial developmental cycle.
Keywords: Type III secretion systems; protein translocation; Chlamydiales; Type III secretion systemeffector proteins; chlamydial; developmental cycle Type III secretion systems; protein translocation; Chlamydiales; Type III secretion systemeffector proteins; chlamydial; developmental cycle

Share and Cite

MDPI and ACS Style

Beeckman, D.S.A.; Vanrompay, D.C.G. Bacterial Secretion Systems with an Emphasis on the Chlamydial Type III Secretion System. Curr. Issues Mol. Biol. 2010, 12, 17-42. https://doi.org/10.21775/cimb.012.017

AMA Style

Beeckman DSA, Vanrompay DCG. Bacterial Secretion Systems with an Emphasis on the Chlamydial Type III Secretion System. Current Issues in Molecular Biology. 2010; 12(1):17-42. https://doi.org/10.21775/cimb.012.017

Chicago/Turabian Style

Beeckman, Delphine Sylvie Anne, and Daisy C.G. Vanrompay. 2010. "Bacterial Secretion Systems with an Emphasis on the Chlamydial Type III Secretion System" Current Issues in Molecular Biology 12, no. 1: 17-42. https://doi.org/10.21775/cimb.012.017

APA Style

Beeckman, D. S. A., & Vanrompay, D. C. G. (2010). Bacterial Secretion Systems with an Emphasis on the Chlamydial Type III Secretion System. Current Issues in Molecular Biology, 12(1), 17-42. https://doi.org/10.21775/cimb.012.017

Article Metrics

Back to TopTop