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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Interplay between Human Leukocyte Antigen Genes and the Microbial Colonization Process of the Newborn Intestine

by
G. De Palma
1,
A. Capilla
2,
I. Nadal
1,
E. Nova
3,
T. Pozo
3,
V. Varea
4,
I. Polanco
5,
G. Castillejo
6,
A. López
7,
J.A. Garrote
8,
C. Calvo
8,
M.D. García-Novo
9,
M.L. Cilleruelo
10,
C. Ribes-Koninckx
7,
F. Palau
2 and
Y. Sanz
1,*
1
Ecofisicologia Microbiana, Instituto de Agroquimica y Tecnologia de Alimentos (CSIC), Valencia, Spain
2
Instituto de Biomedicina de Valencia (CSIC), CIBER de Enfermedades Raras (CIBERER), Valencia, Spain
3
Departmento de Metabolismo y Nutrición, Instituto del Frío- ICTAN (CSIC), Madrid, Spain
4
Gastroenterología, Nutrición y Hepatología Pediátrica, Hospital Universitario Sant Joan de Deu, Barcelona, Spain
5
Servicio de Gastroenterologia y Nutrición Pediátrica, Hospital Universitario La Paz, Madrid, Spain
6
Unidad de Gastroenterología Pediátrica, Hospital Universitario Sant Joan de Reus, Tarragona, Spain
7
Servicio de Gastroenterología Pediátrica, Hospital Universitario La Fe, Valencia, Spain
8
Unidades de Investigación y Pediatría, Hospital Clínico Universitario, Valladolid, Spain
9
Unidad de Gastroenterologia, Hospital Universitario Infantil Niño Jesús, Madrid, Spain
10
Servicio de Pediatría, Hospital Severo Ochoa, Leganés, Madrid, Spain
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2010, 12(1), 1-10; https://doi.org/10.21775/cimb.012.001
Submission received: 6 February 2009 / Revised: 1 March 2009 / Accepted: 7 April 2009 / Published: 28 May 2009
Versions Notes

Abstract

Coeliac disease (CD) development involves genetic (HLA-DQ2/DQ8) and environmental factors. Herein, the influence of the HLA-DQ genotype on the gut colonization process of breast-fed children was determined. A cohort of 20 newborns, with at least one first-degree relative with CD, were classified according to their HLA-DQ genotype into high, intermediate and low genetic risk groups, showing 24-28%, 7-8% and less than 1% probability to develop CD, respectively. Faecal microbiota was analysed at 7 days, 1 and 4 months of children's age by fluorescence in situ hybridization. When considering all data, Gram-negative bacteria and Bacteroides-Prevotella group proportions were higher (P<0.05) in the high than in the intermediate and low genetic risk groups. E. coli, Streptococcus-Lactococcus, E. rectale-C. coccoides, sulphate-reducing bacteria, C. lituseburense and C. histolyticum group proportions were also significantly higher (P<0.05) in the high than in the low genetic risk group. Correlations between these bacterial groups and the genetic risk were also detected (P<0.05). In addition, the number and type of CD relative seemed to influence (P<0.050) these bacterial proportions in children at CD risk. At 4 months of age, similar relationships were established between the high genetic risk to develop CD and the proportions of Streptococcus-Lactococcus (P<0.05), E. rectale-C. coccoides (P<0.05), C. lituseburense (P<0.05), C. histolyticum (P<0.05), Bacteroides-Prevotella (P<0.10) groups and total Gram-negative bacteria (P<0.05). The results suggest a relationship between HLA-DQ genes and the gut microbial colonization process that could lead to a change in the way this disorder is investigated.

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MDPI and ACS Style

De Palma, G.; Capilla, A.; Nadal, I.; Nova, E.; Pozo, T.; Varea, V.; Polanco, I.; Castillejo, G.; López, A.; Garrote, J.A.; et al. Interplay between Human Leukocyte Antigen Genes and the Microbial Colonization Process of the Newborn Intestine. Curr. Issues Mol. Biol. 2010, 12, 1-10. https://doi.org/10.21775/cimb.012.001

AMA Style

De Palma G, Capilla A, Nadal I, Nova E, Pozo T, Varea V, Polanco I, Castillejo G, López A, Garrote JA, et al. Interplay between Human Leukocyte Antigen Genes and the Microbial Colonization Process of the Newborn Intestine. Current Issues in Molecular Biology. 2010; 12(1):1-10. https://doi.org/10.21775/cimb.012.001

Chicago/Turabian Style

De Palma, G., A. Capilla, I. Nadal, E. Nova, T. Pozo, V. Varea, I. Polanco, G. Castillejo, A. López, J.A. Garrote, and et al. 2010. "Interplay between Human Leukocyte Antigen Genes and the Microbial Colonization Process of the Newborn Intestine" Current Issues in Molecular Biology 12, no. 1: 1-10. https://doi.org/10.21775/cimb.012.001

APA Style

De Palma, G., Capilla, A., Nadal, I., Nova, E., Pozo, T., Varea, V., Polanco, I., Castillejo, G., López, A., Garrote, J. A., Calvo, C., García-Novo, M. D., Cilleruelo, M. L., Ribes-Koninckx, C., Palau, F., & Sanz, Y. (2010). Interplay between Human Leukocyte Antigen Genes and the Microbial Colonization Process of the Newborn Intestine. Current Issues in Molecular Biology, 12(1), 1-10. https://doi.org/10.21775/cimb.012.001

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