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3-(1-Cyclohexyl-2-(cyclohexylamino)-4-(4-ethoxyphenyl)-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methylquinoxalin-2(1H)-one
 
 
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Placovinane: 1″β-Ethoxy-6,4′-dimethoxy-3″,3″-dimethyl-1″,2″-dihydropyranoisoflavone, a New Isoflavone Derivative

1
Institute of Environment-Energy Technology, Sai Gon University, Ho Chi Minh City 748355, Vietnam
2
Lu Gia Secondary School, Distr. 11, Ho Chi Minh City 700000, Vietnam
3
Research Unit in Natural Products Chemistry and Bioactivities, Faculty of Science and Technology, Thammasat University Lampang Campus, Lampang 52190, Thailand
*
Authors to whom correspondence should be addressed.
Academic Editors: Oleg A. Rakitin, Fang-Rong Chang and Rodrigo Abonia
Molbank 2022, 2022(3), M1422; https://doi.org/10.3390/M1422
Received: 5 June 2022 / Revised: 22 July 2022 / Accepted: 2 August 2022 / Published: 5 August 2022
(This article belongs to the Section Natural Products)
Isoflavonoids possess a 3-phenylchroman skeleton and are the biologically active secondary metabolites of various plants that are used for different health promoting and restoring effects through a variety of mechanisms. Chromatographic separation of the n-hexane extract from the stems of Placolobium vietnamense led to the isolation of a new isoflavone derivative, placovinane (1), together with four known compounds (25). The structures of isolated compounds were identified from their spectroscopic data and by comparison with the literature. All isolated compounds were evaluated for their α-glucosidase inhibition. They all exhibited potent α-glucosidase inhibition with IC50 values ranging from 11.0 to 87.3 µM, which was significantly less than the positive control acarbose (IC50 179 µM). The cytotoxicity of 1 was evaluated against KB, Hep G2, and MCF7 cell lines, and displayed weak cytotoxicity toward KB and Hep G2 cell lines, with the IC50 values of 89.6 and 93.8 μM, respectively. View Full-Text
Keywords: Placolobium vietnamense; placovinane; isoflavone derivative; α-glucosidase inhibition; cytotoxicity Placolobium vietnamense; placovinane; isoflavone derivative; α-glucosidase inhibition; cytotoxicity
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MDPI and ACS Style

Huynh, T.T.N.; Do, L.T.M.; Sichaem, J. Placovinane: 1″β-Ethoxy-6,4′-dimethoxy-3″,3″-dimethyl-1″,2″-dihydropyranoisoflavone, a New Isoflavone Derivative. Molbank 2022, 2022, M1422. https://doi.org/10.3390/M1422

AMA Style

Huynh TTN, Do LTM, Sichaem J. Placovinane: 1″β-Ethoxy-6,4′-dimethoxy-3″,3″-dimethyl-1″,2″-dihydropyranoisoflavone, a New Isoflavone Derivative. Molbank. 2022; 2022(3):M1422. https://doi.org/10.3390/M1422

Chicago/Turabian Style

Huynh, Tuyet T. N., Lien T. M. Do, and Jirapast Sichaem. 2022. "Placovinane: 1″β-Ethoxy-6,4′-dimethoxy-3″,3″-dimethyl-1″,2″-dihydropyranoisoflavone, a New Isoflavone Derivative" Molbank 2022, no. 3: M1422. https://doi.org/10.3390/M1422

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