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3-Chloro-4-(5-methoxy-1H-indol-3-yl)cyclobut-3-ene-1,2-dione

Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, D-38106 Braunschweig, Germany
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Molbank 2013, 2013(3), M805; https://doi.org/10.3390/M805
Received: 18 April 2013 / Accepted: 10 July 2013 / Published: 22 July 2013
The indole ring system is a prominent partial structure of several protein kinase inhibitor families. The title compound is the first example of a 5-substituted indolyl squaryl chloride with free indole nitrogen. It has been synthesized by reaction of 5-methoxyindole with squaric acid dichloride in diethyl ether and its IR, 1H-NMR, 13C-NMR, MS, UV and HPLC data are presented. This compound may prove to be a rather useful building block for the preparation of various derivatives for biological studies. View Full-Text
Keywords: Friedel-Crafts acylation; indole; squaric acid dichloride Friedel-Crafts acylation; indole; squaric acid dichloride
MDPI and ACS Style

Lande, D.H.; Messal, M.; Reimann, V.; Renger, C.; Rurka, C.; Schoemaker, J.; Schröder, N.K.; Grünefeld, J. 3-Chloro-4-(5-methoxy-1H-indol-3-yl)cyclobut-3-ene-1,2-dione. Molbank 2013, 2013, M805.

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