Next Article in Journal
Synthesis of 6-carbomethoxy-3-Phenyl-5-(4-dimethylaminophenyl)-cyclohexenone
Previous Article in Journal
Synthesis of tridentate Nitrogen Ligand : N,N-bis-(3,5-dimethylpyrazol-1-ylmethyl)benzylamine (NNNN)
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Short Note

Synthesis of New bis-Bidentate Nitrogen Ligand: 1,4-bis[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]piperazine

Laboratoire de Chimie Organique, Département de Chimie, Faculté des Sciences Dhar El Mehraz, Fès, Morocco
Laboratoire d'Analyses, d'Essais et d'Environnement (LAEE), Département de Chimie, Faculté des Sciences Dhar Mehraz, Université Sidi Mohamed Ben Abdellah, 30000 Fès, Morocco
Institut fur Organische Chemie, J. W. Goethe-Universitat Frankfurt, Marie-Curie-Str. 11, 60439 Frankfurt/Main, Germany
Laboratoire d’activation moléculaire, Department of Chemistry, Faculty of Sciences, 60000 Oujda, Morocco
Authors to whom correspondence should be addressed.
Molbank 2005, 2005(6), M451;
Received: 15 July 2005 / Accepted: 24 September 2005 / Published: 12 December 2005
Molbank 2005 m451 i001
The product 2 was prepared by the addition of piperazine (C4H10N2) to 1 [1] according to the reported procedure [2]. To a solution of the substituted hydroxymethylpyrazole 1 (1.26 g, 10 mmol) in acetonitrile (50 ml) was added piperazine (0.95 g, 5 mmol) and the mixture was stirred. The stirring was continued at room temperature for 4 days. The solvent was evaporated under reduced pressure. The solid was cristallised in ethanol to afford 2 as a white solid (2.31 g, 76%).
Melting point: 158-160°C.
IR (KBr, cm– 1): 2270 (CH); 1650 (C=C, C=N).
1H- NMR (60 MHz, CDCl3): δ= 5.8 (s, 2H, Pyrazol, H4,4'); 4.6 (s, 4H, 2NCH2N); 2.6 (s, 8H, 4CH2-N); 2.30 (s, 12H, 4CH3).
13C-NMR (300MHz, D2O): δ= 9.64 (Pz-CH3); 12.12 (Pz-CH3); 69.4 (Pz-CH2-N); 81.75 (N-CH2_CH2_N); 106.38(PzC-H); 141.66 (PzC=N); 149.94(PzC-N).
EI-MS (m/z; %): Calculated for C16H26N6: 302.418. Found: 303[M+1]; 109; 95.

Supplementary materials

Supplementary File 1Supplementary File 2Supplementary File 3


We are indebted to the "Projet Global d’Université Mohamed Premier" for financial support.


  1. Dvoretzky, I.; Richter, G.H. J. Org.Chem. 1950, 15, 1285. [CrossRef]
  2. Sheu, S-C; Tien, M-J.; Cheng, M-C.; Ho, T-I.; Peng, S-M.; Lin, Y-C. J. Chem. Soc. Dalton Trans 1995, 3503–3510.
  • Sample Availability: Available from the authors and MDPI.

Share and Cite

MDPI and ACS Style

El Fatmi, A.; Daoudi, M.; Ben Larbi, N.; Kerbal, A.; Filali Baba, M.; El Bali, B.; Bolte, M.; Mchich, M.; Ben-Hadda, T. Synthesis of New bis-Bidentate Nitrogen Ligand: 1,4-bis[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]piperazine. Molbank 2005, 2005, M451.

AMA Style

El Fatmi A, Daoudi M, Ben Larbi N, Kerbal A, Filali Baba M, El Bali B, Bolte M, Mchich M, Ben-Hadda T. Synthesis of New bis-Bidentate Nitrogen Ligand: 1,4-bis[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]piperazine. Molbank. 2005; 2005(6):M451.

Chicago/Turabian Style

El Fatmi, Abdeljalil, Maria Daoudi, Najib Ben Larbi, Abdelali Kerbal, Mohamed Filali Baba, Brahim El Bali, Michael Bolte, Mohamed Mchich, and Taibi Ben-Hadda. 2005. "Synthesis of New bis-Bidentate Nitrogen Ligand: 1,4-bis[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]piperazine" Molbank 2005, no. 6: M451.

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop