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1,808,897 Results Found

  • Feature Paper
  • Article
  • Open Access

Comparative Efficacy and Immunogenicity of Infliximab and Adalimumab in Crohn’s Disease: A Prospective Cohort Study

  • Luis G. Guijarro,
  • Patricia de Castro-Martínez,
  • María Chaparro,
  • Julio Acero-Sanz,
  • Diego de León,
  • Iván Guerra,
  • Marisa Iborra,
  • José Luis Cabriada,
  • Luis Bujanda and
  • Cristina Alba
  • + 13 authors
Medicina2025, 61(12), 2165;https://doi.org/10.3390/medicina61122165 
(registering DOI)

4 December 2025

Background and Objectives: Crohn’s Disease (CD) is a chronic inflammatory condition often treated with anti-TNF agents such as infliximab (IFX) and adalimumab (ADA). This study compares the efficacy, immunogenicity, and pharmacokinetics of IFX...

  • Article
  • Open Access
Land2025, 14(12), 2377;https://doi.org/10.3390/land14122377 
(registering DOI)

4 December 2025

This study investigates the integration of forestry into strategic planning across territorial levels in the context of the bioeconomy, using the Czech Republic as a case study of an EU member state. This is examined through a qualitative content ana...

  • Review
  • Open Access
Int. J. Mol. Sci.2025, 26(23), 11758;https://doi.org/10.3390/ijms262311758 
(registering DOI)

4 December 2025

Wastewater-derived microplastics (WW–MPs) are increasingly recognised as reactive vectors for aromatic organic contaminants (AOCs), yet their role in contaminant fate remains insufficiently constrained. This review synthesises current knowledge...

  • Article
  • Open Access
Polymers2025, 17(23), 3236;https://doi.org/10.3390/polym17233236 
(registering DOI)

4 December 2025

Thin-walled cellular structures of continuous fiber-reinforced thermoplastic composites (CFRTPCs) have received much attention from both academics and industry due to their superior properties. Additive manufacturing provides an efficient solution fo...

  • Article
  • Open Access

Synthetic Hamiltonian Energy Prediction for Motor Performance Assessment in Neurorehabilitation Procedures: A Machine Learning Approach with TimeGAN-Augmented Data

  • Henry P. Paz-Arias,
  • Omar A. Dominguez-Ramirez,
  • Raúl Villafuerte-Segura,
  • Jeimmy Y. Eche-Salazar and
  • Jose F. Lucio-Naranjo
Robotics2025, 14(12), 183;https://doi.org/10.3390/robotics14120183 
(registering DOI)

4 December 2025

This study presents an assessment scheme for haptic interaction systems based on Hamiltonian energy prediction, which contributes to procedures applied to neurorehabilitation. It focuses on robotic systems involving human participation in the control...

  • Article
  • Open Access
Buildings2025, 15(23), 4395;https://doi.org/10.3390/buildings15234395 
(registering DOI)

4 December 2025

The tensile strength of stabilized clayey soil is a key indicator of its resistance to cracking and directly governs its performance when used as subgrade fill. In this study, ordinary Portland cement and polyacrylate-based super-absorbent polymers (...

  • Article
  • Open Access

Tunable Near-Infrared Laser Emission at 1.7 μm Generated by Stimulated Raman Scattering of Sulfur Hexafluoride Molecules in Anti-Resonant Hollow-Core Fibers

  • Peicong Liu,
  • Tianyu Li,
  • Wenxi Pei,
  • Luohao Lei,
  • Jing Shi,
  • Guorui Lv,
  • Qi Chen,
  • Guangrong Sun,
  • Yamei Xu and
  • Shuyi Wang
  • + 2 authors
Photonics2025, 12(12), 1196;https://doi.org/10.3390/photonics12121196 
(registering DOI)

4 December 2025

Fiber lasers operating at 1.7 μm have significant application value in fields such as gas detection and material processing due to their characteristics, including compact structure and ease of thermal management. Based on the stimulated Raman sca...

  • Article
  • Open Access
J. Mar. Sci. Eng.2025, 13(12), 2309;https://doi.org/10.3390/jmse13122309 
(registering DOI)

4 December 2025

In the present study, numerical simulations were conducted to investigate the behavior of a 60° inclined dense jet discharged onto horizontal (0°) and sloped (5°) bottoms in a stagnant environment. The objective was to evaluate the capabi...

  • Article
  • Open Access

Efficient Removal of Fluorine from Leachate of Spent Lithium Iron Phosphate Calcine by Porous Zirconium-Based Adsorbent

  • Shengqi Gong,
  • Haijun Huang,
  • Yizheng Wang,
  • Fupeng Liu,
  • Zaoming Chen,
  • Tao Jiang,
  • Ruzhen Peng,
  • Jinliang Wang and
  • Xirong Chen
Materials2025, 18(23), 5475;https://doi.org/10.3390/ma18235475 
(registering DOI)

4 December 2025

During the recycling process of spent lithium-ion batteries (LIBs), there is a large number of fluoride ions in the leaching solution. These fluoride ions not only affect the quality of lithium products, but they also have adverse effects on the envi...

  • Article
  • Open Access
Sensors2025, 25(23), 7402;https://doi.org/10.3390/s25237402 
(registering DOI)

4 December 2025

The integration of movable antenna (MA) and reconfigurable intelligent surfaces (RIS) offers promising potential for enhancing simultaneous wireless information and power transfer (SWIPT) systems. In this paper, we investigate a novel MA-enabled RIS-...

  • Article
  • Open Access
Appl. Sci.2025, 15(23), 12852;https://doi.org/10.3390/app152312852 
(registering DOI)

4 December 2025

Ground-penetrating radar (GPR) is widely used for thickness or compaction degree detection of asphalt pavement layers, where the dielectric properties of asphalt mixtures serve as a key parameter influencing detection accuracy. These properties are c...

  • Article
  • Open Access

Difference in Tableting of Lubricated Spray-Dried Mannitol and Fluid-Bed Granulated Isomalt

  • Valentyn Mohylyuk,
  • Kirils Kukuls,
  • Alīna Jaroslava Frolova,
  • Zoltán Márk Horváth,
  • Tetiana Kolisnyk,
  • Elżbieta Maria Buczkowska,
  • Līga Pētersone and
  • Adrien Pelloux
Pharmaceutics2025, 17(12), 1566;https://doi.org/10.3390/pharmaceutics17121566 
(registering DOI)

4 December 2025

Background: Polyols are widely used as tablet diluents due to their high solubility, favourable taste, and ability to form robust tablets. Thus, commercially available polyols, such as mannitol and isomalt, can be considered for the preparation of lo...

  • Article
  • Open Access

Response of Lodging Resistance and Grain Yield to EDAH and Different Fertilization Combinations in Maize (Zea mays L.)

  • Yuru Wang,
  • Yifei Wang,
  • Chenyang Jiang,
  • Yuwen Liang,
  • Genji You,
  • Jian Guo,
  • Dalei Lu and
  • Guanghao Li
Plants2025, 14(23), 3707;https://doi.org/10.3390/plants14233707 
(registering DOI)

4 December 2025

Stalk lodging is one of the major constraints limiting global maize yield. Chemical regulation and fertilization are essential agronomic practices that play critical roles in improving maize yield and lodging resistance. This study aimed to investiga...

  • Article
  • Open Access
J. Imaging2025, 11(12), 433;https://doi.org/10.3390/jimaging11120433 
(registering DOI)

4 December 2025

Accurate segmentation and classification of kidney pathologies from medical images remain a major challenge in computer-aided diagnosis due to complex morphological variations, small lesion sizes, and severe class imbalance. This study introduces Dia...

  • Article
  • Open Access
Healthcare2025, 13(23), 3182;https://doi.org/10.3390/healthcare13233182 
(registering DOI)

4 December 2025

Background: Academic burnout significantly impacts students’ cognitive and psychological well-being and may result in adverse behavioral changes. An effective and timely detection of burnout in the student population is crucial as it enables ed...

  • Review
  • Open Access
Materials2025, 18(23), 5474;https://doi.org/10.3390/ma18235474 
(registering DOI)

4 December 2025

The global challenge of antimicrobial resistance, as well as the need to develop safe and environmentally sustainable materials, has served to stimulate research interest in antimicrobial technologies. The abundance, degradability and environmental f...

  • Article
  • Open Access

Enhancing PRRT Outcome Prediction in Neuroendocrine Tumors: Aggregated Multi-Lesion PET Radiomics Incorporating Inter-Tumor Heterogeneity

  • Maziar Sabouri,
  • Ghasem Hajianfar,
  • Omid Gharibi,
  • Alireza Rafiei Sardouei,
  • Yusuf Menda,
  • Ayca Dundar,
  • Camila Gadens Zamboni,
  • Sanchay Jain,
  • Marc Kruzer and
  • Habib Zaidi
  • + 3 authors
Cancers2025, 17(23), 3887;https://doi.org/10.3390/cancers17233887 
(registering DOI)

4 December 2025

Introduction: Peptide Receptor Radionuclide Therapy (PRRT) with [177Lu]Lu-DOTA-TATE is effective in treating advanced Neuroendocrine Tumors (NETs), yet predicting individual response in this treatment remains a challenge due to inter-lesion heterogen...

  • Article
  • Open Access
Sensors2025, 25(23), 7400;https://doi.org/10.3390/s25237400 
(registering DOI)

4 December 2025

Radio Frequency Identification (RFID) is a core enabler of the Industrial Internet of Things (IIoT), yet dense deployments suffer from tag collisions and reader interference that degrade reliability and inflate infrastructure cost. This study propose...

  • Article
  • Open Access

Localization of Radio Signal Sources for Situational Awareness Enhancement

  • Krzysztof Malon,
  • Paweł Skokowski and
  • Gregor Pavlin
Sensors2025, 25(23), 7401;https://doi.org/10.3390/s25237401 
(registering DOI)

4 December 2025

This article proposes a novel passive localization framework that leverages detection results from existing distributed radio detectors. The intuition behind this solution is to combine positive (signal detected) and negative (signal not detected) de...

  • Article
  • Open Access
Systems2025, 13(12), 1100;https://doi.org/10.3390/systems13121100 
(registering DOI)

4 December 2025

Rapid progress in sustainable and intelligent transportation has intensified interest in smart airport initiatives, driven by the need to support environmentally responsible and technology-enabled aviation development. As complex sociotechnical subsy...

  • Article
  • Open Access
Animals2025, 15(23), 3504;https://doi.org/10.3390/ani15233504 
(registering DOI)

4 December 2025

Kittens are born with some maternally derived antibodies (MDA) that, together with maternal gut microbiota, bring some form of early defense against pathogens. However, this protection declines and the rapid changes and challenges the kitten typicall...

  • Article
  • Open Access

Whole-Genome Sequencing of Dorper × Hu Hybrid Sheep for Screening Selection Signatures Associated with Litter Size

  • Liying Qiao,
  • Ke Ma,
  • Quanhong Yao,
  • Siying Zhang,
  • Zhixu Pang,
  • Wannian Wang,
  • Ke Cai and
  • Wenzhong Liu
Animals2025, 15(23), 3505;https://doi.org/10.3390/ani15233505 
(registering DOI)

4 December 2025

Sheep are an economically important livestock species, and reproductive performance is a key trait affecting productivity. The Dorper × Hu hybrid sheep (DHS), widely bred in China, provides a valuable model for studying the genetic basis of pro...

  • Article
  • Open Access
Sustainability2025, 17(23), 10884;https://doi.org/10.3390/su172310884 
(registering DOI)

4 December 2025

Rural labor transfer is crucial for China’s urbanization and agricultural modernization, yet the role of contracted land assets in this process remains underexplored. Understanding how land tenure arrangements affect labor mobility decisions ha...

  • Article
  • Open Access

Identification of Sulfonamide-Vinyl Sulfone/Chalcone and Berberine-Cinnamic Acid Hybrids as Potent DENV and ZIKV NS2B/NS3 Allosteric Inhibitors

  • Panupong Mahalapbutr,
  • Kowit Hengphasatporn,
  • Wachirapol Manimont,
  • Ladawan Vajarintarangoon,
  • Yasuteru Shigeta,
  • Nayana Bhat,
  • Thitinan Aiebchun,
  • Bodee Nutho,
  • Supot Hannongbua and
  • Thanyada Rungrotmongkol
Int. J. Mol. Sci.2025, 26(23), 11762;https://doi.org/10.3390/ijms262311762 
(registering DOI)

4 December 2025

Dengue virus (DENV) and Zika virus (ZIKV) are flaviviruses transmitted by Aedes spp. mosquitoes, causing a spectrum of symptoms ranging from mild fevers and joint pain to severe damage to vital organs, including the kidneys, brain, and liver. Unfortu...

  • Article
  • Open Access

Preparation of Alginate/AgNP Nanocomposite Hydrogels Incorporating Olive Leaf Extracts in Natural Deep Eutectic Solvents

  • Ioanna Pitterou,
  • Athina Tzavara Roussi,
  • Aikaterini Malliaraki,
  • Elli Martina Kousouli,
  • Andromachi Tzani,
  • Konstantinos Tsiantas,
  • Anthimia Batrinou,
  • Christina Fountzoula,
  • Anastasios Kriebardis and
  • Panagiotis Zoumpoulakis
  • + 1 author
Polymers2025, 17(23), 3234;https://doi.org/10.3390/polym17233234 
(registering DOI)

4 December 2025

In the present study, alginate–silver nanoparticle (Alg-AgNP) nanocomposite hydrogels possessing antibacterial activity were synthesized via an innovative route. A task-specific designed Natural Deep Eutectic Solvent (NADES), composed of glucos...

  • Article
  • Open Access

Diversity and Traditional Uses of Fabaceae Species in Maha Sarakham Province, Thailand

  • Piyaporn Saensouk,
  • Surapon Saensouk,
  • Sawai Mattapha,
  • Khamfa Chanthavongsa and
  • Tammanoon Jitpromma
Diversity2025, 17(12), 838;https://doi.org/10.3390/d17120838 
(registering DOI)

4 December 2025

The Fabaceae family plays a vital role in tropical ecosystems and human livelihoods due to its ecological, nutritional, and medicinal significance. This study provides a comprehensive ethnobotanical assessment of Fabaceae in Maha Sarakham Province, N...

  • Article
  • Open Access

Dentinogenic Effect of BMP-7 on Wharton’s Jelly Mesenchymal Stem Cells Cultured in Decellularized Dental Pulp

  • Nur Athirah Ahmad Shuhaimi,
  • Dalia Abdullah,
  • Farinawati Yazid,
  • Sook Luan Ng,
  • Nurul Inaas Mahamad Apandi and
  • Nur Azurah Abdul Ghani
Int. J. Mol. Sci.2025, 26(23), 11760;https://doi.org/10.3390/ijms262311760 
(registering DOI)

4 December 2025

Decellularized tissue scaffolds mimic the native pulp-dentin microenvironment and support the odontogenic development of stem cells. This study investigated the dentinogenic effect of Wharton’s Jelly Mesenchymal Stem Cells (WJMSCs) in decellula...

  • Review
  • Open Access

Innovations in Biofilm Prevention and Eradication in Medical Sector: An Integrative Review

  • Konrad Niedźwiadek,
  • Magdalena Polak-Berecka and
  • Adam Waśko
Pathogens2025, 14(12), 1242;https://doi.org/10.3390/pathogens14121242 
(registering DOI)

4 December 2025

Background: Biofilm-associated infections remain a major challenge in modern medicine due to their high resistance to antibiotics and immune defences. Advances in materials science, chemistry, and nanotechnology have led to the development of innovat...

  • Article
  • Open Access
Symmetry2025, 17(12), 2086;https://doi.org/10.3390/sym17122086 
(registering DOI)

4 December 2025

The performance of witness-based random search algorithms is highly influenced by the distribution density of witnesses. To optimize this distribution, we propose a novel method based on the symmetric folding of the objective dataset. Our approach in...

  • Article
  • Open Access

A Novel Data-Driven Multi-Agent Reinforcement Learning Approach for Voltage Control Under Weak Grid Support

  • Jiaxin Wu,
  • Ziqi Wang,
  • Ji Han,
  • Qionglin Li,
  • Ran Sun,
  • Chenhao Li,
  • Yuehan Cheng,
  • Bokai Zhou,
  • Jiaming Guo and
  • Bocheng Long
Sensors2025, 25(23), 7399;https://doi.org/10.3390/s25237399 
(registering DOI)

4 December 2025

To address active voltage control in photovoltaic (PV)-integrated distribution networks characterized by weak voltage support conditions, this paper proposes a multi-agent deep reinforcement learning (MADRL)-based coordinated control method for PV cl...

  • Article
  • Open Access

CD74-Targeting Antibody–Drug Conjugate Enhances Immunosuppression of Glucocorticoid in Systemic Lupus Erythematosus

  • Qizhen Du,
  • Shengtao Yao,
  • Yuying Huang,
  • Jia Zhang,
  • Wangmo Sonam,
  • Xiao Lu,
  • Jichao Yang,
  • Shipeng Cheng,
  • Ran Wang and
  • Jiefang Xu
  • + 9 authors
Int. J. Mol. Sci.2025, 26(23), 11761;https://doi.org/10.3390/ijms262311761 
(registering DOI)

4 December 2025

Glucocorticoid drugs (GCs), while effective in systemic lupus erythematosus (SLE), cause severe systemic side effects due to lack of tissue-specificity. To overcome this bottleneck, we developed a CD74-directed antibody–drug conjugate (Bud-ADC)...

  • Article
  • Open Access

4 December 2025

Composite fiber membranes fabricated via rotational-force spinning have become widely applied in biomedicine, energy, and environmental fields owing to their excellent properties. Improving their functional performance and fabrication quality has the...

  • Article
  • Open Access

4 December 2025

Fault diagnosis methods for rolling bearings are frequently constrained to the automatic extraction of single-scale features from raw vibration signals, overlooking crucial information embedded in data of other scales, which often results in unsatisf...

  • Article
  • Open Access

4 December 2025

Steel surface defect detection is critical for ensuring industrial product quality and safety. Although deep learning-based detectors like the YOLO series have demonstrated considerable promise, they often struggle with three key challenges under com...

  • Article
  • Open Access

Coronary Artery Calcification on Non-Cardiac Gated CT Thorax Scans: A Single Tertiary Centre Retrospective Observational Study

  • Robert S. Doyle,
  • Divyanshu Jain,
  • Patrick Devitt,
  • Jack Hartnett,
  • Hugo C. Temperley and
  • Catherine McGorrian

Background: While the 2024 ESC Guidelines provide guidance on utilising incidental CAC findings from non-gated CT scans to enhance risk stratification and guide treatment decisions, there remain gaps in detailed protocols for managing such incidental...

  • Review
  • Open Access

Molecular Mechanisms of the Phytohormone–Heat Shock Protein Pathway in Regulating Plant Thermotolerance

  • Jialiang Zhang,
  • Yanchun Zhu,
  • Fumin Ma,
  • Xiao Zou,
  • Qiuxia Lan,
  • Xiaoran Zhou,
  • Mengxia Li,
  • Fei Zhou,
  • Changxi Yin and
  • Yongjun Lin

4 December 2025

Heat stress caused by global climate change poses a significant threat to agricultural production. Phytohormones, as critical signaling molecules, play pivotal roles in modulating plant responses to heat stress. This review systematically summarizes...

  • Article
  • Open Access

We present a psycholinguistic test battery designed to examine the cognitive and affective processes involved in reading Polish poetry. This toolkit combines reader profiling (vocabulary, memory and reading proficiency) with tasks that assess the inf...

  • Article
  • Open Access

4 December 2025

Hot-melt extrusion produces a solid dispersion (SD) containing a poorly water-soluble drug (k) and matrix polymer surfactant (PS), thereby enhancing k’s solubility. When dissolving the SD, the PS is first dissolved, forming micelles. The amorph...

  • Article
  • Open Access

4 December 2025

Articular cartilage possesses limited intrinsic healing capacity due to its avascular and aneural nature, posing a significant challenge for treating focal chondral defects. While regenerative strategies employing biomaterials and stem cells have pro...

  • Article
  • Open Access

4 December 2025

Blockchain technology is increasingly adopted in supply chains to record product carbon footprints and environmental attributes on tamper-resistant ledgers. By improving the transparency and verifiability of emission-related information for governmen...

  • Short Note
  • Open Access

Bis(1,2,4-triphenylcyclopentadienyl) Terbium 4,4,4-trifluoro-1-phenylbutane-1,3-dionate

  • Daniil A. Bardonov,
  • Mikhail E. Minyaev,
  • Lada N. Puntus,
  • Ilya E. Nifant’ev and
  • Dmitrii M. Roitershtein
Molbank2025, 2025(4), M2102;https://doi.org/10.3390/M2102 
(registering DOI)

4 December 2025

A new bis(cyclopentadienyl) terbium(III) complex with 1,2,4-triphenylcyclopentadienyl and 4,4,4-trifluoro-1-phenylbutane-1,3-dionate ligands was synthesized. Single-crystal X-ray analysis revealed a mononuclear bis(cyclopentadienyl) complex with a di...

  • Article
  • Open Access

4 December 2025

Patients undergoing oral surgery are frequently polymedicated and preoperative prescriptions (analgesics, corticosteroids, antibiotics) can generate clinically significant drug–drug interactions (DDIs) associated with bleeding risk, serotonin t...

  • Article
  • Open Access

Procedural Challenges in Soil Sample Preparation for Pharmaceuticals Analysis

  • Agnieszka Fiszka Borzyszkowska,
  • Ewa Olkowska and
  • Lidia Wolska

4 December 2025

The determination of trace levels of pharmaceuticals in complex environmental samples requires an appropriate sample preparation stage prior to final determination. Currently, special attention should be paid to pharmaceuticals extensively used on in...

  • Article
  • Open Access

Exploratory Immunohistochemical Profiling of FOXP3, PD-1 and CD32B in Resectable Lung Adenocarcinoma

  • Long-Wei Lin,
  • Hong-Jing Chuang,
  • Kuan-Hsun Lian,
  • Yu-Ting Tseng and
  • Chung-Yu Chen

4 December 2025

Background: Regulatory T cells (FOXP3+), checkpoint signaling (PD-1), and inhibitory B-cell signaling (CD32B/FCGR2B) may shape recurrence risk after resection of lung adenocarcinoma, but small, stage-heterogeneous cohorts complicate inference. Method...

  • Article
  • Open Access

4 December 2025

This paper presents a valve-controlled pipeline humidification system aimed at achieving precise and uniform humidity regulation in the multi-layer cultivation environments of plant factories. Since grafted seedlings require stable humidity condition...

  • Review
  • Open Access

The Future of Vertical-Axis Wind Turbines: Opportunities, Challenges, and Sustainability Perspectives

  • Mladen Bošnjaković,
  • Robert Santa,
  • Jelena Topić Božič and
  • Simon Muhič
Energies2025, 18(23), 6369;https://doi.org/10.3390/en18236369 
(registering DOI)

4 December 2025

This Vertical-axis wind turbines (VAWTs) are emerging as promising alternatives to conventional horizontal-axis wind turbines (HAWTs) for renewable energy generation, particularly in urban and offshore environments. Despite increasing interest, a com...

  • Article
  • Open Access

Lupus Nephritis During the COVID-19 Pandemic: Challenges and Implications Before, During, and After

  • Michał Komorniczak,
  • Piotr Stępniewski,
  • Barbara Bułło-Piontecka,
  • Katarzyna Aleksandra Lisowska,
  • Alicja Dębska-Ślizień and
  • Anna Wardowska

Background: Patients with systemic lupus erythematosus (SLE), particularly those with lupus nephritis (LN), are at increased risk of severe COVID-19 outcomes due to immune dysregulation and immunosuppressive therapy. Renal transplant recipients with...

  • Article
  • Open Access

Untargeted Metabolomics Reveals Distinct Soil Metabolic Profiles Across Land Management Practices

  • Zane A. Vickery,
  • Hector F. Castro,
  • Stephen P. Dearth,
  • Eric D. Tague,
  • Aimée T. Classen,
  • Jessica A. Moore,
  • Michael S. Strickland and
  • Shawn R. Campagna
Metabolites2025, 15(12), 783;https://doi.org/10.3390/metabo15120783 
(registering DOI)

4 December 2025

Background/Objectives: Land management practices strongly influence soil biochemical processes, yet conventional soil measurements often overlook dynamic small-molecule variation underlying nutrient cycling and microbial activity. This study aimed to...

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