Special Issue "Novel Properties of Well-Characterized Toxins"

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A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: closed (31 August 2013)

Special Issue Editor

Guest Editor
Prof. Dr. Vernon L. Tesh
Department of Microbial and Molecular Pathogenesis, Medical Research and Education Building, Room 3002, College of Medicine, Texas A&M University System Health Science Center, 8447 State Highway 47, Bryan, TX 77807, USA
Website: http://medicine.tamhsc.edu/basic-sciences/mmp/faculty/vernon-tesh.html
E-Mail: tesh@medicine.tamhsc.edu
Phone: +1 979 436 0357
Fax: +1 979 845 3479
Interests: shiga toxins; verotoxins; ribosome-inactivating proteins; intracellular signaling pathways activated by microbial toxins; ER stress response; regulation of cytokine expression; innate immune response to microbial toxins; microbial pathogenesis

Special Issue Information

Dear Colleagues,

Compounds expressed by microbes and plants originally described to possess toxic activities (e.g., cytotoxins, neurotoxins, enterotoxins, etc.) have proven to be remarkably multifunctional molecules. For example, the capacity of Shiga toxins, a family of cytotoxins expressed by enteric pathogens, to act as ribosome-inactivating proteins was characterized in the 1980’s. Yet, it has recently been shown that in addition to protein synthesis inhibition, Shiga toxins are capable of: i) mediating membrane curvature and invagination; ii) triggering protein kinase signaling cascades upon membrane receptor binding; iii) being routed to multiple intracellular compartments including lysosomes, the endoplasmic reticulum, and nuclear membranes; iv) mediating transcytotic transport across polarized epithelial monolayers without cytotoxicity; v) activating the ribotoxic stress response leading to MAPK activation; vi) activating the ER stress pathway leading to induction of transcription factors and chaperone expression; vii) inducing chemokine expression by human intestinal epithelial cells; viii) inducing cytokine expression by macrophages; ix) altering normal cell cycling; x) altering cytoskeletal elements; and xi) inducing apoptosis in some cell types and inhibiting spontaneous apoptosis in other cells. Thus, these “toxins” activate a myriad of biological processes, many of which may contribute to pathogenesis. The ability to genetically manipulate toxin genes to produce toxoids (mutations that attenuate toxicity) has revealed many heretofore uncharacterized biological properties of toxins. In this special issue of Toxins, we will explore recently described novel properties of well-characterized toxins, discuss their role in pathogenesis, and review potential clinical applications to prevent or ameliorate toxin-mediated disease.

Prof. Dr. Vernon L. Tesh
Guest Editor

 

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs).

Keywords

  • microbial toxins
  • plant toxins
  • biological functions of toxins
  • non-toxic properties of toxins
  • cellular response to toxins
  • pathogenesis

Published Papers (29 papers)

by
Toxins 2010, 2(6), 1300-1317; doi:10.3390/toxins2061300
Received: 14 May 2010; in revised form: 25 May 2010 / Accepted: 28 May 2010 / Published: 1 June 2010
Show/Hide Abstract | Cited by 22 | PDF Full-text (383 KB) | HTML Full-text | XML Full-text

by  and
Toxins 2010, 2(6), 1357-1380; doi:10.3390/toxins2061357
Received: 15 May 2010; Accepted: 7 June 2010 / Published: 9 June 2010
Show/Hide Abstract | Cited by 3 | PDF Full-text (407 KB) | HTML Full-text | XML Full-text

by ,  and
Toxins 2010, 2(6), 1515-1535; doi:10.3390/toxins2061515
Received: 27 April 2010; in revised form: 18 May 2010 / Accepted: 1 June 2010 / Published: 17 June 2010
Show/Hide Abstract | Cited by 1 | PDF Full-text (228 KB) | HTML Full-text | XML Full-text

by ,  and
Toxins 2010, 2(6), 1500-1514; doi:10.3390/toxins2061500
Received: 20 April 2010; in revised form: 30 April 2010 / Accepted: 4 May 2010 / Published: 17 June 2010
Show/Hide Abstract | Cited by 5 | PDF Full-text (353 KB) | HTML Full-text | XML Full-text

by , , ,  and
Toxins 2010, 2(7), 1881-1897; doi:10.3390/toxins2071881
Received: 18 June 2010; in revised form: 6 July 2010 / Accepted: 12 July 2010 / Published: 19 July 2010
Show/Hide Abstract | Cited by 3 | PDF Full-text (599 KB) | HTML Full-text | XML Full-text

by  and
Toxins 2010, 2(8), 1997-2006; doi:10.3390/toxins2081997
Received: 25 June 2010; Accepted: 1 August 2010 / Published: 4 August 2010
Show/Hide Abstract | Cited by 3 | PDF Full-text (760 KB) | HTML Full-text | XML Full-text

by , ,  and
Toxins 2011, 3(5), 453-468; doi:10.3390/toxins3050453
Received: 16 April 2011; in revised form: 26 April 2011 / Accepted: 28 April 2011 / Published: 10 May 2011
Show/Hide Abstract | Cited by 4 | PDF Full-text (454 KB) | HTML Full-text | XML Full-text

by  and
Toxins 2011, 3(7), 884-899; doi:10.3390/toxins3070884
Received: 13 April 2011; in revised form: 14 June 2011 / Accepted: 16 June 2011 / Published: 15 July 2011
Show/Hide Abstract | Cited by 7 | PDF Full-text (425 KB) | HTML Full-text | XML Full-text

by
Toxins 2011, 3(10), 1263-1277; doi:10.3390/toxins3101263
Received: 3 August 2011; in revised form: 10 October 2011 / Accepted: 12 October 2011 / Published: 20 October 2011
Show/Hide Abstract | Cited by 1 | PDF Full-text (322 KB) | HTML Full-text | XML Full-text

by
Toxins 2012, 4(3), 157-190; doi:10.3390/toxins4030157
Received: 16 January 2012; in revised form: 11 February 2012 / Accepted: 19 February 2012 / Published: 1 March 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (642 KB) | HTML Full-text | XML Full-text

by
Toxins 2012, 4(7), 568-579; doi:10.3390/toxins4070568
Received: 14 May 2012; in revised form: 14 July 2012 / Accepted: 21 July 2012 / Published: 23 July 2012
Show/Hide Abstract | Cited by 6 | PDF Full-text (609 KB) | HTML Full-text | XML Full-text

by , , , , ,  and
Toxins 2012, 4(10), 862-877; doi:10.3390/toxins4100862
Received: 30 August 2012; in revised form: 29 September 2012 / Accepted: 8 October 2012 / Published: 18 October 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (763 KB) | HTML Full-text | XML Full-text

by , , ,  and
Toxins 2012, 4(11), 1008-1023; doi:10.3390/toxins4111008
Received: 16 August 2012; in revised form: 8 October 2012 / Accepted: 9 October 2012 / Published: 25 October 2012
Show/Hide Abstract | Cited by 6 | PDF Full-text (315 KB) | HTML Full-text | XML Full-text
abstract graphic

by  and
Toxins 2012, 4(11), 1082-1119; doi:10.3390/toxins4111082
Received: 14 September 2012; in revised form: 22 October 2012 / Accepted: 23 October 2012 / Published: 1 November 2012
Show/Hide Abstract | Cited by 11 | PDF Full-text (673 KB) | HTML Full-text | XML Full-text

by , , ,  and
Toxins 2012, 4(11), 1120-1138; doi:10.3390/toxins4111120
Received: 18 September 2012; in revised form: 18 October 2012 / Accepted: 19 October 2012 / Published: 1 November 2012
Show/Hide Abstract | Cited by 4 | PDF Full-text (1826 KB) | HTML Full-text | XML Full-text

by , ,  and
Toxins 2012, 4(11), 1261-1287; doi:10.3390/toxins4111261
Received: 17 September 2012; in revised form: 1 November 2012 / Accepted: 2 November 2012 / Published: 8 November 2012
Show/Hide Abstract | Cited by 3 | PDF Full-text (445 KB) | HTML Full-text | XML Full-text

by
Toxins 2012, 4(11), 1343-1366; doi:10.3390/toxins4111343
Received: 27 September 2012; in revised form: 12 November 2012 / Accepted: 13 November 2012 / Published: 15 November 2012
Show/Hide Abstract | Cited by 2 | PDF Full-text (949 KB) | HTML Full-text | XML Full-text

by , , , , , , ,  and
Toxins 2012, 4(12), 1517-1534; doi:10.3390/toxins4121517
Received: 22 October 2012; in revised form: 24 November 2012 / Accepted: 6 December 2012 / Published: 14 December 2012
Show/Hide Abstract | PDF Full-text (683 KB) | HTML Full-text | XML Full-text

by  and
Toxins 2013, 5(1), 25-48; doi:10.3390/toxins5010025
Received: 25 October 2012; in revised form: 18 December 2012 / Accepted: 21 December 2012 / Published: 28 December 2012
Show/Hide Abstract | Cited by 1 | PDF Full-text (1333 KB) | HTML Full-text | XML Full-text

by , ,  and
Toxins 2013, 5(1), 106-119; doi:10.3390/toxins5010106
Received: 14 November 2012; in revised form: 14 December 2012 / Accepted: 28 December 2012 / Published: 11 January 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (2810 KB) | HTML Full-text | XML Full-text | Supplementary Files

by  and
Toxins 2013, 5(1), 139-161; doi:10.3390/toxins5010139
Received: 10 September 2012; in revised form: 12 December 2012 / Accepted: 20 December 2012 / Published: 15 January 2013
Show/Hide Abstract | PDF Full-text (310 KB) | HTML Full-text | XML Full-text

by  and
Toxins 2013, 5(4), 743-775; doi:10.3390/toxins5040743
Received: 27 March 2013; in revised form: 5 April 2013 / Accepted: 16 April 2013 / Published: 23 April 2013
Show/Hide Abstract | Cited by 9 | PDF Full-text (961 KB) | HTML Full-text | XML Full-text

by , ,  and
Toxins 2013, 5(5), 912-925; doi:10.3390/toxins5050912
Received: 18 February 2013; in revised form: 19 April 2013 / Accepted: 19 April 2013 / Published: 29 April 2013
Show/Hide Abstract | Cited by 2 | PDF Full-text (216 KB) | HTML Full-text | XML Full-text

by , , , , ,  and
Toxins 2013, 5(5), 926-938; doi:10.3390/toxins5050926
Received: 12 January 2013; in revised form: 27 March 2013 / Accepted: 23 April 2013 / Published: 3 May 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (1621 KB) | HTML Full-text | XML Full-text
abstract graphic

by ,  and
Toxins 2013, 5(6), 1167-1179; doi:10.3390/toxins5061167
Received: 17 May 2013; in revised form: 28 May 2013 / Accepted: 4 June 2013 / Published: 14 June 2013
Show/Hide Abstract | PDF Full-text (647 KB) | HTML Full-text | XML Full-text

by , ,  and
Toxins 2013, 5(7), 1314-1331; doi:10.3390/toxins5071314
Received: 15 May 2013; in revised form: 16 July 2013 / Accepted: 16 July 2013 / Published: 23 July 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (2204 KB) | HTML Full-text | XML Full-text

by , , , ,  and
Toxins 2013, 5(9), 1531-1542; doi:10.3390/toxins5091531
Received: 5 August 2013; in revised form: 30 August 2013 / Accepted: 5 September 2013 / Published: 9 September 2013
Show/Hide Abstract | PDF Full-text (1113 KB) | HTML Full-text | XML Full-text
abstract graphic

by ,  and
Toxins 2013, 5(9), 1664-1681; doi:10.3390/toxins5091664
Received: 30 August 2013; in revised form: 17 September 2013 / Accepted: 17 September 2013 / Published: 24 September 2013
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by ,  and
Toxins 2013, 5(11), 2074-2092; doi:10.3390/toxins5112074
Received: 29 August 2013; in revised form: 31 October 2013 / Accepted: 4 November 2013 / Published: 8 November 2013
Show/Hide Abstract | PDF Full-text (2220 KB) | HTML Full-text | XML Full-text

Last update: 9 December 2013

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