Toxins 2013, 5(1), 25-48; doi:10.3390/toxins5010025
Review

Prevalence, Biogenesis, and Functionality of the Serine Protease Autotransporter EspP

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Received: 25 October 2012; in revised form: 18 December 2012 / Accepted: 21 December 2012 / Published: 28 December 2012
(This article belongs to the Special Issue Novel Properties of Well-Characterized Toxins)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Enterohemorrhagic E. coli (EHEC) causes severe diseases in humans worldwide. One of its virulence factors is EspP, which belongs to the serine protease autotransporters of Enterobacteriaceae (SPATE) family. In this review we recapitulate the current data on prevalence, biogenesis, structural properties and functionality. EspP has been used to investigate mechanistic details of autotransport, and recent studies indicate that this transport mechanism is not autonomous but rather dependent on additional factors. Currently, five subtypes have been identified (EspPα-EspPε), with EspPα being associated with highly virulent EHEC serotypes and isolates from patients with severe disease. EspPα has been shown to degrade major proteins of the complement cascade, namely C3 and C5 and probably interferes with hemostasis by cleavage of coagulation factor V. Furthermore, EspPα is believed to contribute to biofilm formation perhaps by polymerization to rope-like structures. Together with the proteolytic activity, EspPα might ameliorate host colonization and interfere with host response.
Keywords: EspP; EHEC; virulence factor; SPATE; autotransporter; serine protease
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MDPI and ACS Style

Weiss, A.; Brockmeyer, J. Prevalence, Biogenesis, and Functionality of the Serine Protease Autotransporter EspP. Toxins 2013, 5, 25-48.

AMA Style

Weiss A, Brockmeyer J. Prevalence, Biogenesis, and Functionality of the Serine Protease Autotransporter EspP. Toxins. 2013; 5(1):25-48.

Chicago/Turabian Style

Weiss, André; Brockmeyer, Jens. 2013. "Prevalence, Biogenesis, and Functionality of the Serine Protease Autotransporter EspP." Toxins 5, no. 1: 25-48.

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