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Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion
Medical Microbiology and Hygiene, Department of Infectious Diseases, University Hospital Heidelberg, Im Neuenheimer Feld 324, Heidelberg 69120, Germany
* Author to whom correspondence should be addressed.
Received: 30 August 2013; in revised form: 17 September 2013 / Accepted: 17 September 2013 / Published: 24 September 2013
Abstract: Pasteurella multocida toxin (PMT) is a protein toxin found in toxigenic strains of Pasteurella multocida. PMT is the causative agent for atrophic rhinitis in pigs, a disease characterized by loss of nasal turbinate bones due to an inhibition of osteoblast function and an increase in osteoclast activity and numbers. Apart from this, PMT acts as a strong mitogen, protects from apoptosis and has an impact on the differentiation and function of immune cells. Many signaling pathways have been elucidated, however, the effect of these signaling cascades as a means to subvert the host’s immune system are just beginning to unravel.
Keywords: bacterial toxin; Pasteurella multocida; immune evasion; signal transduction; osteoclast; osteoimmunology; carcinogenesis
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Kubatzky, K.F.; Kloos, B.; Hildebrand, D. Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion. Toxins 2013, 5, 1664-1681.
Kubatzky KF, Kloos B, Hildebrand D. Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion. Toxins. 2013; 5(9):1664-1681.
Kubatzky, Katharina F.; Kloos, Bianca; Hildebrand, Dagmar. 2013. "Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion." Toxins 5, no. 9: 1664-1681.