Toxins 2013, 5(9), 1664-1681; doi:10.3390/toxins5091664
Review

Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion

Medical Microbiology and Hygiene, Department of Infectious Diseases, University Hospital Heidelberg, Im Neuenheimer Feld 324, Heidelberg 69120, Germany
* Author to whom correspondence should be addressed.
Received: 30 August 2013; in revised form: 17 September 2013 / Accepted: 17 September 2013 / Published: 24 September 2013
(This article belongs to the Special Issue Novel Properties of Well-Characterized Toxins)
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Abstract: Pasteurella multocida toxin (PMT) is a protein toxin found in toxigenic strains of Pasteurella multocida. PMT is the causative agent for atrophic rhinitis in pigs, a disease characterized by loss of nasal turbinate bones due to an inhibition of osteoblast function and an increase in osteoclast activity and numbers. Apart from this, PMT acts as a strong mitogen, protects from apoptosis and has an impact on the differentiation and function of immune cells. Many signaling pathways have been elucidated, however, the effect of these signaling cascades as a means to subvert the host’s immune system are just beginning to unravel.
Keywords: bacterial toxin; Pasteurella multocida; immune evasion; signal transduction; osteoclast; osteoimmunology; carcinogenesis

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MDPI and ACS Style

Kubatzky, K.F.; Kloos, B.; Hildebrand, D. Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion. Toxins 2013, 5, 1664-1681.

AMA Style

Kubatzky KF, Kloos B, Hildebrand D. Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion. Toxins. 2013; 5(9):1664-1681.

Chicago/Turabian Style

Kubatzky, Katharina F.; Kloos, Bianca; Hildebrand, Dagmar. 2013. "Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion." Toxins 5, no. 9: 1664-1681.

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