Next Article in Journal
Faces of a Changing Climate: Semi-Quantitative Multi-Mycotoxin Analysis of Grain Grown in Exceptional Climatic Conditions in Norway
Next Article in Special Issue
Shiga Toxin Type 2dact Displays Increased Binding to Globotriaosylceramide in vitro and Increased Lethality in Mice after Activation by Elastase
Previous Article in Journal
Influence of Carbohydrates on Secondary Metabolism in Fusarium avenaceum
Previous Article in Special Issue
CD28: Direct and Critical Receptor for Superantigen Toxins
Article Menu

Export Article

Open AccessReview
Toxins 2013, 5(9), 1664-1681; doi:10.3390/toxins5091664

Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion

Medical Microbiology and Hygiene, Department of Infectious Diseases, University Hospital Heidelberg, Im Neuenheimer Feld 324, Heidelberg 69120, Germany
*
Author to whom correspondence should be addressed.
Received: 30 August 2013 / Revised: 17 September 2013 / Accepted: 17 September 2013 / Published: 24 September 2013
(This article belongs to the Special Issue Novel Properties of Well-Characterized Toxins)
View Full-Text   |   Download PDF [459 KB, uploaded 24 September 2013]   |  

Abstract

Pasteurella multocida toxin (PMT) is a protein toxin found in toxigenic strains of Pasteurella multocida. PMT is the causative agent for atrophic rhinitis in pigs, a disease characterized by loss of nasal turbinate bones due to an inhibition of osteoblast function and an increase in osteoclast activity and numbers. Apart from this, PMT acts as a strong mitogen, protects from apoptosis and has an impact on the differentiation and function of immune cells. Many signaling pathways have been elucidated, however, the effect of these signaling cascades as a means to subvert the host’s immune system are just beginning to unravel. View Full-Text
Keywords: bacterial toxin; Pasteurella multocida; immune evasion; signal transduction; osteoclast; osteoimmunology; carcinogenesis bacterial toxin; Pasteurella multocida; immune evasion; signal transduction; osteoclast; osteoimmunology; carcinogenesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kubatzky, K.F.; Kloos, B.; Hildebrand, D. Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion. Toxins 2013, 5, 1664-1681.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top