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Toxins 2010, 2(8), 1997-2006; doi:10.3390/toxins2081997

Distribution of Gb3 Immunoreactivity in the Mouse Central Nervous System

*  and
Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 W. Baltimore St. HSFI suite 380, Baltimore, MD 21201, USA
* Author to whom correspondence should be addressed.
Received: 25 June 2010 / Accepted: 1 August 2010 / Published: 4 August 2010
(This article belongs to the Special Issue Novel Properties of Well-Characterized Toxins)
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We have shown previously that neurons in the mouse spinal cord express Gb3. We show in this article that distribution of anti-Gb3-Ab reactivity occurs in many different types of neurons of different areas of the central nervous system (CNS). The immunoreactive neurons are in olfactory bulbs, cerebral cortex, hippocampus, striatum, amygdala, thalamus, hypothalamus, cerebellum, and medulla oblongata. In several different circumventricular organs where vessels do not have the blood-brain-barrier (BBB) structure, anti-Gb3-Ab is not positive for vessel structures, while neurons at these regions are positive. Also, within the ventricular area, ependymal cells in the third ventricle express Gb3, as revealed by anti-Gb3-Ab staining and intensity analysis.
Keywords: globotriaosylceramide (Gb3); neuron; circumventricular organs (CVO); ependymal cells globotriaosylceramide (Gb3); neuron; circumventricular organs (CVO); ependymal cells
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Obata, F.; Obrig, T. Distribution of Gb3 Immunoreactivity in the Mouse Central Nervous System. Toxins 2010, 2, 1997-2006.

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