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Toxins 2012, 4(3), 157-190; doi:10.3390/toxins4030157

The Interactions of Human Neutrophils with Shiga Toxins and Related Plant Toxins: Danger or Safety?

Dipartimento di Patologia Sperimentale, Università di Bologna, Via San Giacomo 14, 40126 Bologna, Italy
Received: 16 January 2012 / Revised: 11 February 2012 / Accepted: 19 February 2012 / Published: 1 March 2012
(This article belongs to the Special Issue Novel Properties of Well-Characterized Toxins)
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Abstract

Shiga toxins and ricin are well characterized similar toxins belonging to quite different biological kingdoms. Plant and bacteria have evolved the ability to produce these powerful toxins in parallel, while humans have evolved a defense system that recognizes molecular patterns common to foreign molecules through specific receptors expressed on the surface of the main actors of innate immunity, namely monocytes and neutrophils. The interactions between these toxins and neutrophils have been widely described and have stimulated intense debate. This paper is aimed at reviewing the topic, focusing particularly on implications for the pathogenesis and diagnosis of hemolytic uremic syndrome.
Keywords: Shiga toxins; ricin; ribosome-inactivating proteins; polymorphonuclear leukocytes; hemolytic uremic syndrome Shiga toxins; ricin; ribosome-inactivating proteins; polymorphonuclear leukocytes; hemolytic uremic syndrome
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Brigotti, M. The Interactions of Human Neutrophils with Shiga Toxins and Related Plant Toxins: Danger or Safety? Toxins 2012, 4, 157-190.

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