Toxins 2011, 3(7), 884-899; doi:10.3390/toxins3070884
Article

Gi/o Protein-Dependent and -Independent Actions of Pertussis Toxin (PTX)

Received: 13 April 2011; in revised form: 14 June 2011 / Accepted: 16 June 2011 / Published: 15 July 2011
(This article belongs to the Special Issue Novel Properties of Well-Characterized Toxins)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Pertussis toxin (PTX) is a typical A-B toxin. The A-protomer (S1 subunit) exhibits ADP-ribosyltransferase activity. The B-oligomer consists of four subunits (S2 to S5) and binds extracellular molecules that allow the toxin to enter the cells. The A-protomer ADP-ribosylates the α subunits of heterotrimeric Gi/o proteins, resulting in the receptors being uncoupled from the Gi/o proteins. The B-oligomer binds proteins expressed on the cell surface, such as Toll-like receptor 4, and activates an intracellular signal transduction cascade. Thus, PTX modifies cellular responses by at least two different signaling pathways; ADP-ribosylation of the Gαi/o proteins by the A-protomer (Gi/o protein-dependent action) and the interaction of the B-oligomer with cell surface proteins (Gi/o protein-independent action).
Keywords: A-protomer; ADP-ribosylation; B-oligomer; Gi/o-dependent; Gi/o-independent; heterotrimeric G protein; G protein-coupled receptor; pertussis toxin; Toll-like receptor 4
PDF Full-text Download PDF Full-Text [425 KB, Updated Version, uploaded 18 July 2011 09:27 CEST]
The original version is still available [425 KB, uploaded 15 July 2011 14:54 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Mangmool, S.; Kurose, H. Gi/o Protein-Dependent and -Independent Actions of Pertussis Toxin (PTX). Toxins 2011, 3, 884-899.

AMA Style

Mangmool S, Kurose H. Gi/o Protein-Dependent and -Independent Actions of Pertussis Toxin (PTX). Toxins. 2011; 3(7):884-899.

Chicago/Turabian Style

Mangmool, Supachoke; Kurose, Hitoshi. 2011. "Gi/o Protein-Dependent and -Independent Actions of Pertussis Toxin (PTX)." Toxins 3, no. 7: 884-899.

Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert