Special Issue "Recent Advances and Perspectives in Deoxynivalenol Research"
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: closed (20 December 2013)
Dr. Marc Maresca
Aix Marseille Université, CNRS, iSm2 UMR 7313, Marseille 13397, France
Interests: gut physiology; intestinal epithelial cells; intestinal toxicology ; enterotoxins; bacterial toxins; virotoxins; mycotoxins; trichothecenes; deoxynivalenol; nutrient absorption
From many years, the food-associated trichothecene mycotoxin Deoxynivalenol (DON or vomitoxin) has attracted the attention of scientists (http://www.mdpi.com/2072-6651/5/4/784). This is due for part to its high prevalence in animal/human food and feed products as demonstrated through the successful use of urinary biomarkers confirming the exposure of humans to substantial doses of this toxin. DON is also one of the most hazardous mycotoxins, this toxin affecting the functions of nervous, endocrine, immune and intestinal cells. In addition to its toxicity to animal cells (that could be considered as a collateral damage), DON is also known to affect plant cells functions, such effects certainly playing a role during the colonization of wheat and cereals by DON-producing fungi such as Fusarium species. The toxicity of DON seems to depend on the presence an epoxide function allowing its binding to ribosomes, causing the so-called “ribotoxic stress” effect, the activation of specific kinases (including PKR and MAP kinases) and eventually leading to the inhibition of the protein synthesis and to cell death. Due to its ability to activate PKR and MAP kinases, DON also acts as a proinflammatory signal at low doses whereas higher doses are immunosuppressive due to cellular toxicity. In animals, in addition to affect the systemic and the intestinal immunity, DON also impacts the functions of the brain and endocrine cells, causing anorexia and vomiting. Food not only contains native toxin, but also large amounts of plant and fungal derivatives of DON (including the fungal metabolites 3 and 15 acetyl-DON (3 and 15ADON) and the plant derivative 3-O-glucoside-DON (D3G)) and possibly, although no study has yet confirmed it, of animal derivatives (i.e., 3 and 15-glucuronide DON) potentially present in meat and animal-derived products. New DON derivatives were furthermore recently found in plants and food products, including DON-oligoglycosides, DON-glutathione, DON-S-Cysteine, DON-S-Cysteinyl-glycine, DON-sulfonate. Although previous research has brought light on the mechanisms of action of DON, important questions remain. For example, little is known on the ability of the fungi to be transmitted from the soil to the cereals and on the levels of DON and DON metabolites in different plant tissues during natural and experimental contamination. Data on the effects of DON and its metabolites on plant cells are also scarce. Similarly, how DON enters the cells (animal or plant cells) and how it binds / acts on ribosomes is not perfectly characterized. Finally, if ribosomes are the only target of DON, how the toxin could activate different kinases depending of the dose of toxin remains a mystery. We hope some of these questions will be answered in this special issue focusing on one of the most studied and relevant food-associated mycotoxin.
Dr. Marc Maresca
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- cell entry
- cell effect
- DON derivative