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Toxins 2013, 5(4), 784-820; doi:10.3390/toxins5040784

From the Gut to the Brain: Journey and Pathophysiological Effects of the Food-Associated Trichothecene Mycotoxin Deoxynivalenol

Aix Marseille Université, CNRS, iSm2 UMR 7313, Marseille 13397, France
Received: 25 February 2013 / Revised: 11 April 2013 / Accepted: 12 April 2013 / Published: 23 April 2013
(This article belongs to the Special Issue Recent Advances and Perspectives in Deoxynivalenol Research)
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Abstract

Mycotoxins are fungal secondary metabolites contaminating food and causing toxicity to animals and humans. Among the various mycotoxins found in crops used for food and feed production, the trichothecene toxin deoxynivalenol (DON or vomitoxin) is one of the most prevalent and hazardous. In addition to native toxins, food also contains a large amount of plant and fungal derivatives of DON, including acetyl-DON (3 and 15ADON), glucoside-DON (D3G), and potentially animal derivatives such as glucuronide metabolites (D3 and D15GA) present in animal tissues (e.g., blood, muscle and liver tissue). The present review summarizes previous and very recent experimental data collected in vivo and in vitro regarding the transport, detoxification/metabolism and physiological impact of DON and its derivatives on intestinal, immune, endocrine and neurologic functions during their journey from the gut to the brain. View Full-Text
Keywords: deoxynivalenol; mycotoxin; trichothecene; detoxification; intestinal absorption; intestine; brain; endocrine; glial cells; immune cells deoxynivalenol; mycotoxin; trichothecene; detoxification; intestinal absorption; intestine; brain; endocrine; glial cells; immune cells
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Maresca, M. From the Gut to the Brain: Journey and Pathophysiological Effects of the Food-Associated Trichothecene Mycotoxin Deoxynivalenol. Toxins 2013, 5, 784-820.

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