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Toxins 2013, 5(11), 2281-2292; doi:10.3390/toxins5112281
Article

The Expression of Type-1 and Type-2 Nitric Oxide Synthase in Selected Tissues of the Gastrointestinal Tract during Mixed Mycotoxicosis

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Received: 11 October 2013; in revised form: 12 November 2013 / Accepted: 18 November 2013 / Published: 22 November 2013
(This article belongs to the Special Issue Recent Advances and Perspectives in Deoxynivalenol Research)
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Abstract: The aim of the study was to verify the hypothesis that intoxication with low doses of mycotoxins leads to changes in the mRNA expression levels of nitric oxide synthase-1 and nitric oxide synthase-2 genes in tissues of the gastrointestinal tract and the liver. The experiment involved four groups of immature gilts (with body weight of up to 25 kg) which were orally administered zearalenone in a daily dose of 40 μg/kg BW (group Z, n = 18), deoxynivalenol at 12 μg/kg BW (group D, n = 18), zearalenone and deoxynivalenol (group M, n = 18) or placebo (group C, n = 21) over a period of 42 days. The lowest mRNA expression levels of nitric oxide synthase-1 and nitric oxide synthase-2 genes were noted in the sixth week of the study, in particular in group M. Our results suggest that the presence of low mycotoxin doses in feed slows down the mRNA expression of both nitric oxide synthase isomers, which probably lowers the concentrations of nitric oxide, a common precursor of inflammation.
Keywords: mycotoxins; low doses; zearalenone; deoxynivalenol; gene expression; nitric oxide synthases mycotoxins; low doses; zearalenone; deoxynivalenol; gene expression; nitric oxide synthases
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Gajęcka, M.; Stopa, E.; Tarasiuk, M.; Zielonka, Ł.; Gajęcki, M. The Expression of Type-1 and Type-2 Nitric Oxide Synthase in Selected Tissues of the Gastrointestinal Tract during Mixed Mycotoxicosis. Toxins 2013, 5, 2281-2292.

AMA Style

Gajęcka M, Stopa E, Tarasiuk M, Zielonka Ł, Gajęcki M. The Expression of Type-1 and Type-2 Nitric Oxide Synthase in Selected Tissues of the Gastrointestinal Tract during Mixed Mycotoxicosis. Toxins. 2013; 5(11):2281-2292.

Chicago/Turabian Style

Gajęcka, Magdalena; Stopa, Ewa; Tarasiuk, Michał; Zielonka, Łukasz; Gajęcki, Maciej. 2013. "The Expression of Type-1 and Type-2 Nitric Oxide Synthase in Selected Tissues of the Gastrointestinal Tract during Mixed Mycotoxicosis." Toxins 5, no. 11: 2281-2292.



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