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Toxins 2014, 6(1), 1-19; doi:10.3390/toxins6010001
Review

Deoxynivalenol: A Major Player in the Multifaceted Response of Fusarium to Its Environment

1,* , 1
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Received: 24 October 2013; in revised form: 16 December 2013 / Accepted: 16 December 2013 / Published: 19 December 2013
(This article belongs to the Special Issue Recent Advances and Perspectives in Deoxynivalenol Research)
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Abstract: The mycotoxin deoxynivalenol (DON), produced by several Fusarium spp., acts as a virulence factor and is essential for symptom development after initial wheat infection. Accumulating evidence shows that the production of this secondary metabolite can be triggered by diverse environmental and cellular signals, implying that it might have additional roles during the life cycle of the fungus. Here, we review data that position DON in the saprophytic fitness of Fusarium, in defense and in the primary C and N metabolism of the plant and the fungus. We combine the available information in speculative models on the role of DON throughout the interaction with the host, providing working hypotheses that await experimental validation. We also highlight the possible impact of control measures in the field on DON production and summarize the influence of abiotic factors during processing and storage of food and feed matrices. Altogether, we can conclude that DON is a very important compound for Fusarium to cope with a changing environment and to assure its growth, survival, and production of toxic metabolites in diverse situations.
Keywords: trichothecene; oxidative stress; virulence factor; fungicides; primary metabolism trichothecene; oxidative stress; virulence factor; fungicides; primary metabolism
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Audenaert, K.; Vanheule, A.; Höfte, M.; Haesaert, G. Deoxynivalenol: A Major Player in the Multifaceted Response of Fusarium to Its Environment. Toxins 2014, 6, 1-19.

AMA Style

Audenaert K, Vanheule A, Höfte M, Haesaert G. Deoxynivalenol: A Major Player in the Multifaceted Response of Fusarium to Its Environment. Toxins. 2014; 6(1):1-19.

Chicago/Turabian Style

Audenaert, Kris; Vanheule, Adriaan; Höfte, Monica; Haesaert, Geert. 2014. "Deoxynivalenol: A Major Player in the Multifaceted Response of Fusarium to Its Environment." Toxins 6, no. 1: 1-19.


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