Topical Collection "Molecular Research in Neurotoxicology"
Dr. G. Jean Harry (Website)
Neurotoxicology Group, NIEHS and National Toxicology Program, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA
Fax: +1 919 541 4611
Interests: neurotoxicants; aging; development; inflammation; oxidative stress; signal transduction; hormones; neuropathology; pharmaceuticals; alternative models
Alterations in nervous system functioning as a result of environmental factors, pharmaceuticals, genetic variability, and health status remain an issue of concern for human health. Recent advancements have been made in our understanding of common biological processes related to neurotoxicity associated with disease states and age-related or genetic vulnerabilities. These advances have been possible due to the ability to examine molecular aspects underlying neurodevelopment, neurodegeneration, and associated processes of neurotoxicity. The integration of this molecular data into the field of neurotoxicology, as it applies to the broad spectrum of environmental exposure now offers a mechanistic framework for understanding the dynamics of neurotoxicity. Further work on epigenetic mechanisms associated with nervous system functioning, e.g., learning and memory, provide additional mechanisms by which regulation of the nervous system can be altered by environmental exposure or by which events occurring during early life stages can influence responses later in life. This topical collection will focus on the integration of established biological processes and molecular events as they relate to the regulation of cellular and functional changes within the nervous system and how this may contribute to neurotoxicity. The collection will include aspects of neurological and neurodegenerative disease, neurodevelopmental disorders, and specific neurotoxicity from environmental or pharmaceutical agents. We are seeking novel research and/or review articles highlighting 1) the variety of molecular signals and integrated networks that underlie adverse responses in the nervous system, 2) how these alterations in molecular signaling translate to alterations in the structure or function of the nervous system (biochemical, physiology, behavior), 3) molecular events occurring during early life that can shift susceptibility in the adult, 4) epigenetic regulatory events as they contribute to neurotoxicity and 5) contributions to life stage events influencing human health.
Dr. G. Jean Harry
Manuscript Submission Information
Manuscripts for the topical collection can be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on this website. The topical collection considers regular research articles, short communications and review articles. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.
- oxidative stress
- organophosphorus pesticides
- neuropathy target esterase (nte)
- animal models
- transcription factor signaling
- cell death
- receptor mediated events
- neural cell differentiation
- quinolinic acid
- heat shock protein 70
- neurotrophic factors
- heavy metals
- pharmacological models
- perinatal brain injury
- neurodegenerative diseases