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Int. J. Mol. Sci. 2015, 16(3), 5400-5419; doi:10.3390/ijms16035400

A Heme Oxygenase-1 Transducer Model of Degenerative and Developmental Brain Disorders

1
Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T1E2, Canada
2
Department of Neurology & Neurosurgery and Department of Medicine, McGill University and Jewish General Hospital, Montreal, QC H3T1E2, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: G. Jean Harry
Received: 11 December 2014 / Revised: 28 January 2015 / Accepted: 22 February 2015 / Published: 9 March 2015
(This article belongs to the Special Issue Molecular Research in Neurotoxicology)
View Full-Text   |   Download PDF [4591 KB, uploaded 9 March 2015]   |  

Abstract

Heme oxygenase-1 (HO-1) is a 32 kDa protein which catalyzes the breakdown of heme to free iron, carbon monoxide and biliverdin. The Hmox1 promoter contains numerous consensus sequences that render the gene exquisitely sensitive to induction by diverse pro-oxidant and inflammatory stimuli. In “stressed” astroglia, HO-1 hyperactivity promotes mitochondrial iron sequestration and macroautophagy and may thereby contribute to the pathological iron deposition and bioenergetic failure documented in Alzheimer disease, Parkinson disease and certain neurodevelopmental conditions. Glial HO-1 expression may also impact neuroplasticity and cell survival by modulating brain sterol metabolism and the proteasomal degradation of neurotoxic proteins. The glial HO-1 response may represent a pivotal transducer of noxious environmental and endogenous stressors into patterns of neural damage and repair characteristic of many human degenerative and developmental CNS disorders. View Full-Text
Keywords: Alzheimer disease; astrocyte; carbon monoxide; heme oxygenase-1; iron; macroautophagy; mitochondria; oxidative stress; Parkinson disease; schizophrenia Alzheimer disease; astrocyte; carbon monoxide; heme oxygenase-1; iron; macroautophagy; mitochondria; oxidative stress; Parkinson disease; schizophrenia
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Schipper, H.M.; Song, W. A Heme Oxygenase-1 Transducer Model of Degenerative and Developmental Brain Disorders. Int. J. Mol. Sci. 2015, 16, 5400-5419.

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