Int. J. Mol. Sci. 2013, 14(8), 16817-16835; doi:10.3390/ijms140816817
Review

Gene Expression Profiling as a Tool to Investigate the Molecular Machinery Activated during Hippocampal Neurodegeneration Induced by Trimethyltin (TMT) Administration

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Received: 23 July 2013; in revised form: 6 August 2013 / Accepted: 8 August 2013 / Published: 15 August 2013
(This article belongs to the collection Molecular Research in Neurotoxicology)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Trimethyltin (TMT) is an organotin compound exhibiting neurotoxicant effects selectively localized in the limbic system and especially marked in the hippocampus, in both experimental animal models and accidentally exposed humans. TMT administration causes selective neuronal death involving either the granular neurons of the dentate gyrus or the pyramidal cells of the Cornu Ammonis, with a different pattern of localization depending on the different species studied or the dosage schedule. TMT is broadly used to realize experimental models of hippocampal neurodegeneration associated with cognitive impairment and temporal lobe epilepsy, though the molecular mechanisms underlying the associated selective neuronal death are still not conclusively clarified. Experimental evidence indicates that TMT-induced neurodegeneration is a complex event involving different pathogenetic mechanisms, probably acting differently in animal and cell models, which include neuroinflammation, intracellular calcium overload, and oxidative stress. Microarray-based, genome-wide expression analysis has been used to investigate the molecular scenario occurring in the TMT-injured brain in different in vivo and in vitro models, producing an overwhelming amount of data. The aim of this review is to discuss and rationalize the state-of-the-art on TMT-associated genome wide expression profiles in order to identify comparable and reproducible data that may allow focusing on significantly involved pathways.
Keywords: trimethyltin; neurodegeneration; gene expression profiling; hippocampus; animal models; cell culture
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MDPI and ACS Style

Lattanzi, W.; Corvino, V.; Di Maria, V.; Michetti, F.; Geloso, M.C. Gene Expression Profiling as a Tool to Investigate the Molecular Machinery Activated during Hippocampal Neurodegeneration Induced by Trimethyltin (TMT) Administration. Int. J. Mol. Sci. 2013, 14, 16817-16835.

AMA Style

Lattanzi W, Corvino V, Di Maria V, Michetti F, Geloso MC. Gene Expression Profiling as a Tool to Investigate the Molecular Machinery Activated during Hippocampal Neurodegeneration Induced by Trimethyltin (TMT) Administration. International Journal of Molecular Sciences. 2013; 14(8):16817-16835.

Chicago/Turabian Style

Lattanzi, Wanda; Corvino, Valentina; Di Maria, Valentina; Michetti, Fabrizio; Geloso, Maria C. 2013. "Gene Expression Profiling as a Tool to Investigate the Molecular Machinery Activated during Hippocampal Neurodegeneration Induced by Trimethyltin (TMT) Administration." Int. J. Mol. Sci. 14, no. 8: 16817-16835.


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