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Int. J. Mol. Sci. 2013, 14(11), 23103-23128; doi:10.3390/ijms141123103

Oxidative Stress Mechanisms Underlying Parkinson’s Disease-Associated Neurodegeneration in C. elegans

1
Neuroscience Graduate Program, Vanderbilt University Medical Center, Nashville, TN 37232, USA
2
Center in Molecular Toxicology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
3
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
4
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
*
Author to whom correspondence should be addressed.
Received: 14 August 2013 / Revised: 8 October 2013 / Accepted: 16 October 2013 / Published: 21 November 2013
(This article belongs to the collection Molecular Research in Neurotoxicology)
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Abstract

Oxidative stress is thought to play a significant role in the development and progression of neurodegenerative diseases. Although it is currently considered a hallmark of such processes, the interweaving of a multitude of signaling cascades hinders complete understanding of the direct role of oxidative stress in neurodegeneration. In addition to its extensive use as an aging model, some researchers have turned to the invertebrate model Caenorhabditis elegans (C. elegans) in order to further investigate molecular mediators that either exacerbate or protect against reactive oxygen species (ROS)-mediated neurodegeneration. Due to their fully characterized genome and short life cycle, rapid generation of C. elegans genetic models can be useful to study upstream markers of oxidative stress within interconnected signaling pathways. This report will focus on the roles of C. elegans homologs for the oxidative stress-associated transcription factor Nrf2, as well as the autosomal recessive, early-onset Parkinson’s disease (PD)-associated proteins Parkin, DJ-1, and PINK1, in neurodegenerative processes.
Keywords: oxidative stress; neurodegeneration; Parkinson’s disease; C. elegans; DJ-1; Parkin; PINK1; Nrf2 oxidative stress; neurodegeneration; Parkinson’s disease; C. elegans; DJ-1; Parkin; PINK1; Nrf2
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chakraborty, S.; Bornhorst, J.; Nguyen, T.T.; Aschner, M. Oxidative Stress Mechanisms Underlying Parkinson’s Disease-Associated Neurodegeneration in C. elegans. Int. J. Mol. Sci. 2013, 14, 23103-23128.

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