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Int. J. Mol. Sci. 2015, 16(3), 4800-4813; doi:10.3390/ijms16034800

Extracellular Vesicles in Alzheimer’s Disease: Friends or Foes? Focus on Aβ-Vesicle Interaction

1
CNR Institute of Neuroscience, via Vanvitelli 32, 20129 Milano, Italy
2
Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy
3
Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, via Olgettina 60, 20132 Milano, Italy
4
IRCCS Humanitas, via Manzoni 56, 20089 Rozzano, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: G. Jean Harry
Received: 23 December 2014 / Revised: 16 February 2015 / Accepted: 17 February 2015 / Published: 3 March 2015
(This article belongs to the Special Issue Molecular Research in Neurotoxicology)
View Full-Text   |   Download PDF [1133 KB, uploaded 3 March 2015]   |  

Abstract

The intercellular transfer of amyloid-β (Aβ) and tau proteins has received increasing attention in Alzheimer’s disease (AD). Among other transfer modes, Aβ and tau dissemination has been suggested to occur through release of Extracellular Vesicles (EVs), which may facilitate delivery of pathogenic proteins over large distances. Recent evidence indicates that EVs carry on their surface, specific molecules which bind to extracellular Aβ, opening the possibility that EVs may also influence Aβ assembly and synaptotoxicity. In this review we focus on studies which investigated the impact of EVs in Aβ-mediated neurodegeneration and showed either detrimental or protective role for EVs in the pathology. View Full-Text
Keywords: Extracellular Vesicles; Aβ assembly; neurodegeneration; oligomeric Aβ; toxcicity Extracellular Vesicles; Aβ assembly; neurodegeneration; oligomeric Aβ; toxcicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Joshi, P.; Benussi, L.; Furlan, R.; Ghidoni, R.; Verderio, C. Extracellular Vesicles in Alzheimer’s Disease: Friends or Foes? Focus on Aβ-Vesicle Interaction. Int. J. Mol. Sci. 2015, 16, 4800-4813.

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