Topical Collection "G Protein-Coupled Receptor Signaling and Regulation"

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A topical collection in International Journal of Molecular Sciences (ISSN 1422-0067). This collection belongs to the section "Biochemistry, Molecular Biology and Biophysics".

Editor

Collection Editor
Prof. Dr. Kathleen Van Craenenbroeck
Laboratory for Eukaryotic Gene Expression and Signal Transduction, Department Physiology University of Gent INW N1 Proeftuinstraat 86, B-9000 Gent, Belgium
Website: http://www.legest.ugent.be/kathleen.html
E-Mail: kathleen.vancraenenbroeck@ugent.be
Interests: GPCR signaling and regulation; epigenetic regulation; anti-inflammatory strategies with less ‘side-effects’

Topical Collection Information

Dear Colleagues,

I am editing a Topical Collection entitled "G Protein-Coupled Receptor Signaling and Regulation". We are seeking novel research or review articles focusing on proteins interacting with GPCRs and by doing so modulating GPCR expression, ligand selectivity and/or signaling.

We look forward to receiving your contributions to this exciting Topical Collection.

Prof. Dr. Kathleen Van Craenenbroeck
Collection Editor

Manuscript Submission Information

Manuscripts for the topical collection can be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on this website. The topical collection considers regular research articles, short communications and review articles. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs).

Keywords

  • GPCR
  • regulation
  • expression
  • signaling
  • dimerization
  • internalization
  • maturation
  • ubiquitination

Published Papers (22 papers)

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2014  ( 19 papers )


2013  ( 3 papers )


2014
by ,  and
Int. J. Mol. Sci. 2014, 15(9), 15412-15425; doi:10.3390/ijms150915412
Received: 24 June 2014; in revised form: 26 July 2014 / Accepted: 20 August 2014 / Published: 1 September 2014
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by , , , , ,  and
Int. J. Mol. Sci. 2014, 15(9), 15161-15172; doi:10.3390/ijms150915161
Received: 19 June 2014; in revised form: 15 August 2014 / Accepted: 21 August 2014 / Published: 27 August 2014
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by , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(6), 10892-10907; doi:10.3390/ijms150610892
Received: 17 April 2014; in revised form: 16 May 2014 / Accepted: 30 May 2014 / Published: 17 June 2014
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by , ,  and
Int. J. Mol. Sci. 2014, 15(6), 10479-10491; doi:10.3390/ijms150610479
Received: 20 April 2014; in revised form: 10 May 2014 / Accepted: 13 May 2014 / Published: 11 June 2014
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by , , , , , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(5), 8570-8590; doi:10.3390/ijms15058570
Received: 19 December 2013; in revised form: 26 March 2014 / Accepted: 30 April 2014 / Published: 14 May 2014
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by  and
Int. J. Mol. Sci. 2014, 15(5), 7841-7864; doi:10.3390/ijms15057841
Received: 20 January 2014; in revised form: 2 April 2014 / Accepted: 9 April 2014 / Published: 6 May 2014
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by ,  and
Int. J. Mol. Sci. 2014, 15(4), 6169-6183; doi:10.3390/ijms15046169
Received: 20 December 2013; in revised form: 14 March 2014 / Accepted: 3 April 2014 / Published: 11 April 2014
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by , , ,  and
Int. J. Mol. Sci. 2014, 15(4), 6252-6264; doi:10.3390/ijms15046252
Received: 27 January 2014; in revised form: 10 March 2014 / Accepted: 1 April 2014 / Published: 11 April 2014
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by , ,  and
Int. J. Mol. Sci. 2014, 15(4), 5884-5906; doi:10.3390/ijms15045884
Received: 2 December 2013; in revised form: 15 March 2014 / Accepted: 25 March 2014 / Published: 8 April 2014
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by ,  and
Int. J. Mol. Sci. 2014, 15(3), 4837-4855; doi:10.3390/ijms15034837
Received: 28 January 2014; in revised form: 6 March 2014 / Accepted: 11 March 2014 / Published: 19 March 2014
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by , , , ,  and
Int. J. Mol. Sci. 2014, 15(3), 4856-4877; doi:10.3390/ijms15034856
Received: 7 January 2014; in revised form: 28 February 2014 / Accepted: 4 March 2014 / Published: 19 March 2014
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by , ,  and
Int. J. Mol. Sci. 2014, 15(2), 2929-2945; doi:10.3390/ijms15022929
Received: 6 December 2013; in revised form: 24 January 2014 / Accepted: 12 February 2014 / Published: 20 February 2014
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by ,  and
Int. J. Mol. Sci. 2014, 15(2), 3003-3024; doi:10.3390/ijms15023003
Received: 26 November 2013; in revised form: 30 December 2013 / Accepted: 12 February 2014 / Published: 20 February 2014
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by ,  and
Int. J. Mol. Sci. 2014, 15(2), 2554-2572; doi:10.3390/ijms15022554
Received: 18 December 2013; in revised form: 17 January 2014 / Accepted: 28 January 2014 / Published: 13 February 2014
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by , , ,  and
Int. J. Mol. Sci. 2014, 15(2), 2024-2052; doi:10.3390/ijms15022024
Received: 20 December 2013; in revised form: 15 January 2014 / Accepted: 15 January 2014 / Published: 28 January 2014
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by , , , , , , , , ,  and
Int. J. Mol. Sci. 2014, 15(1), 1481-1498; doi:10.3390/ijms15011481
Received: 30 November 2013; in revised form: 8 January 2014 / Accepted: 13 January 2014 / Published: 21 January 2014
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by , , , ,  and
Int. J. Mol. Sci. 2014, 15(1), 1574-1589; doi:10.3390/ijms15011574
Received: 25 November 2013; in revised form: 16 December 2013 / Accepted: 3 January 2014 / Published: 21 January 2014
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by  and
Int. J. Mol. Sci. 2014, 15(1), 1112-1142; doi:10.3390/ijms15011112
Received: 4 December 2013; in revised form: 20 December 2013 / Accepted: 8 January 2014 / Published: 16 January 2014
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by , , ,  and
Int. J. Mol. Sci. 2014, 15(1), 629-653; doi:10.3390/ijms15010629
Received: 29 November 2013; in revised form: 20 December 2013 / Accepted: 24 December 2013 / Published: 6 January 2014
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2013
by  and
Int. J. Mol. Sci. 2014, 15(1), 361-376; doi:10.3390/ijms15010361
Received: 2 December 2013; in revised form: 17 December 2013 / Accepted: 19 December 2013 / Published: 31 December 2013
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by  and
Int. J. Mol. Sci. 2013, 14(12), 24726-24741; doi:10.3390/ijms141224726
Received: 21 November 2013; in revised form: 12 December 2013 / Accepted: 13 December 2013 / Published: 18 December 2013
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by , ,  and
Int. J. Mol. Sci. 2013, 14(10), 20236-20255; doi:10.3390/ijms141020236
Received: 16 August 2013; in revised form: 15 September 2013 / Accepted: 16 September 2013 / Published: 11 October 2013
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Novel Therapeutic GPCRs for Psychiatric Disorders
Author: Hidetoshi Komatsu
Affiliation: Novartis Pharma, Medical Division, CNS Medical Franchise Department, Japan
Abstract: G protein-coupled receptors (GPCRs) constitute one of the most important therapeutic repertoires and cover approximately thirty percent of all the current drug targets. Especially, most of the neuropharmacological drugs are targeted to GPCRs in the central nervous system (CNS). GPCRs respond to manifold neurotransmitters and then their activations evoke slow synaptic transmission. GPCRs are well-known to be deeply involved in multiple neurological and psychiatric disorders such as Parkinson's disease and schizophrenia. In brain, the striatum is the origin of dopaminergic cell bodies of the mesocorticolimbic dopamine system and plays a central role in manifestation of psychiatric disorders. Recently, anatomical and comprehensive transcriptome analysis of 322 non-odorant GPCRs revealed that GPR88, GPR6, and GPR52, known as orphan GPCRs, as well as dopamine D1 and D2 receptors and adenosine A2a receptor are the most highly enriched in rodent striatum. Among these three orphan GPCRs, GPR52 co-localizes with a D2 dopamine receptor in neurons of the basal ganglia and is Gs-coupled and responsive to the antipsychotic drug, reserpine. Intriguingly, GPR52 knockout and transgenic mice show psychosis-related and antipsychotic-like behaviors, respectively. This review summarizes the current understanding of potential therapeutic GPCRs for psychiatric disorders together with their anatomical expression profiles.
Keywords: Psychiatric disorders; striatum; schizophrenia; GPCR; GPR52; dopamine receptors; GPR88; GPR6

Last update: 12 May 2014

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert