Function and Regulation of Heterotrimeric G Proteins during Chemotaxis
AbstractChemotaxis, or directional movement towards an extracellular gradient of chemicals, is necessary for processes as diverse as finding nutrients, the immune response, metastasis and wound healing. Activation of G-protein coupled receptors (GPCRs) is at the very base of the chemotactic signaling pathway. Chemotaxis starts with binding of the chemoattractant to GPCRs at the cell-surface, which finally leads to major changes in the cytoskeleton and directional cell movement towards the chemoattractant. Many chemotaxis pathways that are directly regulated by Gβγ have been identified and studied extensively; however, whether Gα is just a handle that regulates the release of Gβγ or whether Gα has its own set of distinct chemotactic effectors, is only beginning to be understood. In this review, we will discuss the different levels of regulation in GPCR signaling and the downstream pathways that are essential for proper chemotaxis. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Kamp, M.E.; Liu, Y.; Kortholt, A. Function and Regulation of Heterotrimeric G Proteins during Chemotaxis. Int. J. Mol. Sci. 2016, 17, 90.
Kamp ME, Liu Y, Kortholt A. Function and Regulation of Heterotrimeric G Proteins during Chemotaxis. International Journal of Molecular Sciences. 2016; 17(1):90.Chicago/Turabian Style
Kamp, Marjon E.; Liu, Youtao; Kortholt, Arjan. 2016. "Function and Regulation of Heterotrimeric G Proteins during Chemotaxis." Int. J. Mol. Sci. 17, no. 1: 90.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.