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Int. J. Mol. Sci. 2014, 15(1), 361-376; doi:10.3390/ijms15010361
Review

Chemokine Receptors in Epithelial Ovarian Cancer

 and
*
Department of Biopharmaceutical Sciences, University of Illinois at Chicago, 833 S Wood Street, PHARM335, Chicago, IL 60612, USA
* Author to whom correspondence should be addressed.
Received: 2 December 2013 / Revised: 17 December 2013 / Accepted: 19 December 2013 / Published: 31 December 2013
(This article belongs to the collection G Protein-Coupled Receptor Signaling and Regulation)
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Abstract

Ovarian carcinoma is the deadliest gynecologic malignancy with very poor rate of survival, and it is characterized by the presence of vast incurable peritoneal metastasis. Studies of the role of chemokine receptors, a family of proteins belonging to the group of G protein-coupled receptors, in ovarian carcinoma strongly placed this family of membrane receptors as major regulators of progression of this malignancy. In this review, we will discuss the roles that chemokine-receptor interactions play to support angiogenesis, cell proliferation, migration, adhesion, invasion, metastasis, and immune evasion in progression of ovarian carcinoma. Data regarding the role that the chemokine receptors play in the disease progression accumulated insofar strongly suggest that this family of proteins could be good therapeutic targets against ovarian carcinoma.
Keywords: ovarian carcinoma; chemokine receptor; metastasis; angiogenesis; invasion; migration; proliferation; immune response ovarian carcinoma; chemokine receptor; metastasis; angiogenesis; invasion; migration; proliferation; immune response
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Muralidhar, G.G.; Barbolina, M.V. Chemokine Receptors in Epithelial Ovarian Cancer. Int. J. Mol. Sci. 2014, 15, 361-376.

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