Next Article in Journal / Special Issue
Dimers of G-Protein Coupled Receptors as Versatile Storage and Response Units
Previous Article in Journal
Identification of the Novel Interacting Partners of the Mammalian Target of Rapamycin Complex 1 in Human CCRF-CEM and HEK293 Cells
Previous Article in Special Issue
Recent Progress in Understanding Subtype Specific Regulation of NMDA Receptors by G Protein Coupled Receptors (GPCRs)
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(3), 4837-4855; doi:10.3390/ijms15034837

The Growth Hormone Secretagogue Receptor: Its Intracellular Signaling and Regulation

1
Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China
2
Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109-0346, USA
*
Author to whom correspondence should be addressed.
Received: 28 January 2014 / Revised: 6 March 2014 / Accepted: 11 March 2014 / Published: 19 March 2014
(This article belongs to the collection G Protein-Coupled Receptor Signaling and Regulation)
View Full-Text   |   Download PDF [239 KB, uploaded 19 June 2014]

Abstract

The growth hormone secretagogue receptor (GHSR), also known as the ghrelin receptor, is involved in mediating a wide variety of biological effects of ghrelin, including: stimulation of growth hormone release, increase of food intake and body weight, modulation of glucose and lipid metabolism, regulation of gastrointestinal motility and secretion, protection of neuronal and cardiovascular cells, and regulation of immune function. Dependent on the tissues and cells, activation of GHSR may trigger a diversity of signaling mechanisms and subsequent distinct physiological responses. Distinct regulation of GHSR occurs at levels of transcription, receptor interaction and internalization. Here we review the current understanding on the intracellular signaling pathways of GHSR and its modulation. An overview of the molecular structure of GHSR is presented first, followed by the discussion on its signaling mechanisms. Finally, potential mechanisms regulating GHSR are reviewed.
Keywords: ghrelin receptor; constitutive activity; intracellular signaling; [Ca2+]i; AMPK; mTOR; MAPK; PI3K ghrelin receptor; constitutive activity; intracellular signaling; [Ca2+]i; AMPK; mTOR; MAPK; PI3K
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Yin, Y.; Li, Y.; Zhang, W. The Growth Hormone Secretagogue Receptor: Its Intracellular Signaling and Regulation. Int. J. Mol. Sci. 2014, 15, 4837-4855.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top