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Int. J. Mol. Sci. 2014, 15(12), 22365-22373; doi:10.3390/ijms151222365

Molecular Actions of Ovarian Cancer G Protein-Coupled Receptor 1 Caused by Extracellular Acidification in Bone

1
Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
2
Department of Orthopaedics and Central Laboratory, the Third Hospital Affiliated of Nantong University, Wuxi 214041, China
*
Author to whom correspondence should be addressed.
Received: 28 September 2014 / Revised: 13 November 2014 / Accepted: 17 November 2014 / Published: 3 December 2014
(This article belongs to the Collection G Protein-Coupled Receptor Signaling and Regulation)
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Abstract

Extracellular acidification occurs under physiologic and pathologic conditions, such as exercise, ischemia, and inflammation. It has been shown that acidosis has various adverse effects on bone. In recent years there has been increasing evidence which indicates that ovarian cancer G protein-coupled receptor 1 (OGR1) is a pH-sensing receptor and mediates a variety of extracellular acidification-induced actions on bone cells and other cell types. Recent studies have shown that OGR1 is involved in the regulation of osteoclast differentiation, survival, and function, as well as osteoblast differentiation and bone formation. Moreover, OGR1 also regulates acid-induced apoptosis of endplate chondrocytes in intervertebral discs. These observations demonstrate the importance of OGR1 in skeletal development and metabolism. Here, we provide an overview of OGR1 regulation ofosteoclasts, osteoblasts, and chondrocytes, and the molecular actions of OGR1 induced by extracellular acidification in the maintenance of bone health. View Full-Text
Keywords: extracellular acidification; OGR1; osteoclasts; osteoblasts; endplate chondrocytes extracellular acidification; OGR1; osteoclasts; osteoblasts; endplate chondrocytes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yuan, F.-L.; Zhao, M.-D.; Jiang, L.-B.; Wang, H.-R.; Cao, L.; Zhou, X.-G.; Li, X.-L.; Dong, J. Molecular Actions of Ovarian Cancer G Protein-Coupled Receptor 1 Caused by Extracellular Acidification in Bone. Int. J. Mol. Sci. 2014, 15, 22365-22373.

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