G Protein-Coupled Receptor Signaling in Stem Cells and Cancer
AbstractG protein-coupled receptors (GPCRs) are a large superfamily of cell-surface signaling proteins that bind extracellular ligands and transduce signals into cells via heterotrimeric G proteins. GPCRs are highly tractable drug targets. Aberrant expression of GPCRs and G proteins has been observed in various cancers and their importance in cancer stem cells has begun to be appreciated. We have recently reported essential roles for G protein-coupled receptor 84 (GPR84) and G protein subunit Gαq in the maintenance of cancer stem cells in acute myeloid leukemia. This review will discuss how GPCRs and G proteins regulate stem cells with a focus on cancer stem cells, as well as their implications for the development of novel targeted cancer therapies. View Full-Text
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Lynch, J.R.; Wang, J.Y. G Protein-Coupled Receptor Signaling in Stem Cells and Cancer. Int. J. Mol. Sci. 2016, 17, 707.
Lynch JR, Wang JY. G Protein-Coupled Receptor Signaling in Stem Cells and Cancer. International Journal of Molecular Sciences. 2016; 17(5):707.Chicago/Turabian Style
Lynch, Jennifer R.; Wang, Jenny Y. 2016. "G Protein-Coupled Receptor Signaling in Stem Cells and Cancer." Int. J. Mol. Sci. 17, no. 5: 707.
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