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Int. J. Mol. Sci. 2016, 17(5), 707; doi:10.3390/ijms17050707

G Protein-Coupled Receptor Signaling in Stem Cells and Cancer

Cancer and Stem Cell Biology Group, Children’s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW 2052, Australia
Centre for Childhood Cancer Research, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia
Author to whom correspondence should be addressed.
Academic Editor: Kathleen Van Craenenbroeck
Received: 1 March 2016 / Revised: 5 May 2016 / Accepted: 5 May 2016 / Published: 11 May 2016
(This article belongs to the Collection G Protein-Coupled Receptor Signaling and Regulation)
View Full-Text   |   Download PDF [1257 KB, uploaded 11 May 2016]   |  


G protein-coupled receptors (GPCRs) are a large superfamily of cell-surface signaling proteins that bind extracellular ligands and transduce signals into cells via heterotrimeric G proteins. GPCRs are highly tractable drug targets. Aberrant expression of GPCRs and G proteins has been observed in various cancers and their importance in cancer stem cells has begun to be appreciated. We have recently reported essential roles for G protein-coupled receptor 84 (GPR84) and G protein subunit Gαq in the maintenance of cancer stem cells in acute myeloid leukemia. This review will discuss how GPCRs and G proteins regulate stem cells with a focus on cancer stem cells, as well as their implications for the development of novel targeted cancer therapies. View Full-Text
Keywords: GPCR; G proteins; signaling; stem cells; cancer stem cells; therapy GPCR; G proteins; signaling; stem cells; cancer stem cells; therapy

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lynch, J.R.; Wang, J.Y. G Protein-Coupled Receptor Signaling in Stem Cells and Cancer. Int. J. Mol. Sci. 2016, 17, 707.

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