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Search Results (2)

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Keywords = vitamin K/gold nanoparticles

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22 pages, 7735 KiB  
Article
Mitigation of Breast Cancer Cells’ Invasiveness via Down Regulation of ETV7, Hippo, and PI3K/mTOR Pathways by Vitamin D3 Gold-Nanoparticles
by Moumita Roy and Fazle Hussain
Int. J. Mol. Sci. 2024, 25(10), 5348; https://doi.org/10.3390/ijms25105348 - 14 May 2024
Cited by 1 | Viewed by 1904
Abstract
Metastasis in breast cancer is the major cause of death in females (about 30%). Based on our earlier observation that Vitamin D3 downregulates mTOR, we hypothesized that Vitamin D3 conjugated to gold nanoparticles (VD3-GNPs) reduces breast cancer aggressiveness by downregulating the key cancer [...] Read more.
Metastasis in breast cancer is the major cause of death in females (about 30%). Based on our earlier observation that Vitamin D3 downregulates mTOR, we hypothesized that Vitamin D3 conjugated to gold nanoparticles (VD3-GNPs) reduces breast cancer aggressiveness by downregulating the key cancer controller PI3K/AKT/mTOR. Western blots, migration/invasion assays, and other cell-based, biophysical, and bioinformatics studies are used to study breast cancer cell aggressiveness and nanoparticle characterization. Our VD3-GNP treatment of breast cancer cells (MCF-7 and MDA-MB-231) significantly reduces the aggressiveness (cancer cell migration and invasion rates > 45%) via the simultaneous downregulation of ETV7 and the Hippo pathway. Consistent with our hypothesis, we, indeed, found a downregulation of the PI3K/AKT/mTOR pathway. It is surprising that the extremely low dose of VD3 in the nano formulation (three orders of magnitude lower than in earlier studies) is quite effective in the alteration of cancer invasiveness and cell signaling pathways. Clearly, VD3-GNPs are a viable candidate for non-toxic, low-cost treatment for reducing breast cancer aggressiveness. Full article
(This article belongs to the Section Molecular Nanoscience)
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21 pages, 5281 KiB  
Article
Processes and Interactions Impacting the Stability and Compatibility of Vitamin K and Gold Nanoparticles
by Adriana Samide, Bogdan Tutunaru and Bogdan Oprea
Processes 2022, 10(9), 1805; https://doi.org/10.3390/pr10091805 - 7 Sep 2022
Cited by 4 | Viewed by 2403
Abstract
This study provides evidence on the stability of vitamin K1 (VK) in the form of phytomenadione, in the absence and presence of a therapeutic preparation, as the gold nanoparticles (AuNPs), under the effect of sodium halide ions. The degradation susceptibility of the [...] Read more.
This study provides evidence on the stability of vitamin K1 (VK) in the form of phytomenadione, in the absence and presence of a therapeutic preparation, as the gold nanoparticles (AuNPs), under the effect of sodium halide ions. The degradation susceptibility of the two compounds was assessed individually and in mixtures by cyclic voltammetry and electrolysis at a constant current density assisted by UV-Vis spectrophotometry. Their interactions with the halide ions differently impact on the electrochemical processes as follows: (i) the fluoride ions weakly affects the VK/AuNP stability and compatibility; (ii) the presence of chloride ions leads to VK/AuNP stability, for a short time and restrictive compatibility; (iii) bromide ions induce instability and incompatibility of the VK/AuNP system; (iv) spontaneous interactions between VK/AuNPs and iodide ions take place, consequently defining as an unstable and incompatible system. Full article
(This article belongs to the Special Issue Application of Nanomaterials in the Process of Water Electrolysis)
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