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Keywords = violapyrones

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9 pages, 614 KB  
Article
Violapyrones H and I, New Cytotoxic Compounds Isolated from Streptomyces sp. Associated with the Marine Starfish Acanthaster planci
by Hee Jae Shin, Hwa-Sun Lee, Jong Seok Lee, Junho Shin, Min Ah Lee, Hyi-Seung Lee, Yeon-Ju Lee, Jieun Yun and Jong Soon Kang
Mar. Drugs 2014, 12(6), 3283-3291; https://doi.org/10.3390/md12063283 - 30 May 2014
Cited by 34 | Viewed by 8253
Abstract
Two new α-pyrone derivatives, violapyrones H (1) and I (2), along with known violapyrones B (3) and C (4) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. The strain was derived [...] Read more.
Two new α-pyrone derivatives, violapyrones H (1) and I (2), along with known violapyrones B (3) and C (4) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. The strain was derived from a crown-of-thorns starfish, Acanthaster planci, collected from Chuuk, Federated States of Micronesia. The structures of violapyrones were elucidated by the analysis of 1D and 2D NMR and HR-ESIMS data. Violapyrones (14) exhibited cytotoxicity against 10 human cancer cell lines with GI50 values of 1.10–26.12 μg/mL when tested using sulforhodamine B (SRB) assay. This is the first report on the cytotoxicity of violapyrones against cancer cell lines and the absolute configuration of violapyrone C. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes)
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