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Keywords = vinylogous amides and esters

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13 pages, 5166 KB  
Article
Photoredox-Catalyzed Giese Reactions: Decarboxylative Additions to Cyclic Vinylogous Amides and Esters
by Kevin Dykstra, Alexei Buevich, Qi Gao, Yu-Hong Lam and Jeffrey T. Kuethe
Molecules 2022, 27(2), 417; https://doi.org/10.3390/molecules27020417 - 10 Jan 2022
Cited by 1 | Viewed by 3866
Abstract
An effective strategy has been developed for the photoredox-catalyzed decarboxylative addition of cyclic amino acids to both vinylogous amides and esters leading to uniquely substituted heterocycles. The additions take place exclusively trans to the substituent present on the dihydropyridone ring affording stereochemical control [...] Read more.
An effective strategy has been developed for the photoredox-catalyzed decarboxylative addition of cyclic amino acids to both vinylogous amides and esters leading to uniquely substituted heterocycles. The additions take place exclusively trans to the substituent present on the dihydropyridone ring affording stereochemical control about the new carbon-carbon bond. These reactions are operationally simplistic and afford the desired products in good to excellent isolated yields. Full article
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