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Rapid urbanization has led to drastic land-use/cover changes (LUCCs) and urban heat islands (UHIs), negatively altering the urban climate and air quality. LUCC’s significant impacts on human health and energy consumption have inspired researchers to develop nature-based solutions to mitigate UHIs and improve air quality. However, integrating GIS-CFD modeling for urban heat mitigation towards climate change adaptation was largely neglected for eco-sustainable urban design in rapidly urbanizing areas. In this study, (1) long-term LUCC and meteorological analysis were conducted in the Wuhan metropolitan area from 1980 to 2016; (2) to mitigate the adverse effects of LUCC under a speedy development process, the role and relevance of optimizing building morphology and urban block configuration were discussed; (3) and particular design attention in strategy towards climate change adaptation for environmental performance improvement was paid in Wuhan’s fast-growing zones. The results show that UHII in 1980 was less severe than in 2016. Air temperature (Ta) increased by 0.4 °C on average per decade in developing areas. This increases the severity of UHII in urban fringes. It is found obligatory for a nature-based design to adopt urban morphology indicators (UMIs) such as average building height (μBH), sky view factors (ψ_SVF), and building density (BD/λ_p = % of built area) towards these changes. Further, on-site measurement revealed that λ_p is the most effective indicator for increasing urban heat around the buildings and boosting UHII. Using UMIs and a combined three-in-one regulation strategy based on μBH of common building types of high-rise (BH^A), mid-rise (BH^B), and low-rise (BH^C) buildings can effectively contribute to regulating Ta and air movement within block configuration. As a result of this study’s strategy, urban heat is mitigated via reinforcing wind in order to adapt to climate change, which impacts the quality of life directly in developing areas. Full article