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Keywords = tripeptide arginine-glycine-aspartic acid (RGD) recognition pattern

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16 pages, 2194 KiB  
Article
Dendritic Scaffold onto Titanium Implants. A Versatile Strategy Increasing Biocompatibility
by Noemi Molina, Ana González, Donato Monopoli, Belinda Mentado, José Becerra, Leonor Santos-Ruiz, Yolanda Vida and Ezequiel Perez-Inestrosa
Polymers 2020, 12(4), 770; https://doi.org/10.3390/polym12040770 - 1 Apr 2020
Cited by 7 | Viewed by 3997
Abstract
Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally been solved by coating the former with “organic” [...] Read more.
Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally been solved by coating the former with “organic” ceramics, such as hydroxyapatite. A novel approach is hereby presented, immobilizing covalently dendrimeric structures onto titanium implants. Amide-based amino terminal dendrons were synthetized and coupled to titanium surfaces in a versatile and controlled way. The dendritic moieties provide an excellent scaffold for the covalent immobilization of bioactive molecules, such as extracellular matrix (ECM) protein components or antibiotics. Herein, tripeptide arginine-glycine-aspartic acid (RGD) motifs were used to decorate the dendritic scaffolds and their influence on cell adhesion and proliferation processes was evaluated. Full article
(This article belongs to the Special Issue Polymeric Materials for Dental Applications)
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