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Keywords = trilateral Rb

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18 pages, 15756 KB  
Review
Subsequent Malignant Neoplasms in Retinoblastoma Survivors
by Armida W. M. Fabius, Milo van Hoefen Wijsard, Flora E. van Leeuwen and Annette C. Moll
Cancers 2021, 13(6), 1200; https://doi.org/10.3390/cancers13061200 - 10 Mar 2021
Cited by 22 | Viewed by 3787
Abstract
Retinoblastoma (Rb) is a pediatric malignant eye tumor. Subsequent malignant neoplasms (SMNs) and trilateral Rb (TRb) are the leading cause of death in heritable Rb patients in developed countries. The high rate of SMNs in heritable Rb patients is attributed to the presence [...] Read more.
Retinoblastoma (Rb) is a pediatric malignant eye tumor. Subsequent malignant neoplasms (SMNs) and trilateral Rb (TRb) are the leading cause of death in heritable Rb patients in developed countries. The high rate of SMNs in heritable Rb patients is attributed to the presence of a mutation in the RB1 tumor suppressor gene. In addition, Rb therapy choices also influence SMN incidence in this patient group. The incidence rates and age of occurrence for the most frequent SMNs and TRb will be discussed. In addition, the impact of genetic predisposition and Rb treatments on the development of SMNs will be evaluated. Furthermore, screening and other prevention methods will be reviewed. Full article
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