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Cross-docking has emerged as a critical logistics strategy to reduce lead times, lower inventory levels, and enhance supply chain responsiveness. However, in high-throughput terminals, efficient coordination of inbound and outbound trailers remains a complex task, especially under uncertain and dynamically changing conditions. We propose a practical framework that helps logistics terminals assign trailers to docks in real time. It links live sensor data with a mathematical optimization model, so that the system can quickly adjust trailer plans when traffic or workload changes. Real-time data from IoT sensors, GPS, and operational records are preprocessed, enriched with predictive analytics, and used as input for a Mixed-Integer Linear Programming (MILP) model solved in rolling horizons. This enables the continuous reallocation of inbound and outbound trailers, ensuring synchronized flows and balanced dock utilization. Numerical experiments compare the adaptive approach with conventional first-come-first-served scheduling. Results show that average inbound dock utilization improves from 68% to 71%, while the share of periods with full utilization increases from 33.3% to 41.4%. Outbound utilization also rises from 57% to 62%. Moreover, trailer delays are significantly reduced, and the overall makespan shortens from 45 to 40 time slots. These findings confirm that adaptive, real-time trailer assignment can enhance efficiency, reliability, and resilience in cross-docking operations. The proposed framework thus bridges the gap between static optimization models and the operational requirements of modern, high-throughput logistics hubs. Full article