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Keywords = thrombin-based hemostatic agent

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11 pages, 3119 KiB  
Systematic Review
Effects of Thrombin-Based Hemostatic Agent in Total Knee Arthroplasty: Meta-Analysis
by Jung-Wee Park, Tae Woo Kim, Chong Bum Chang, Minji Han, Jong Jin Go, Byung Kyu Park, Woo-Lam Jo and Young-Kyun Lee
J. Clin. Med. 2023, 12(20), 6656; https://doi.org/10.3390/jcm12206656 - 20 Oct 2023
Cited by 1 | Viewed by 2063
Abstract
The effectiveness of Floseal, a thrombin-based hemostatic matrix, in total knee arthroplasty (TKA) in minimizing blood loss and transfusion requirements remains a topic of debate. This meta-analysis aims to evaluate the up-to-date randomized controlled trials (RCTs) on the efficacy and safety of Floseal [...] Read more.
The effectiveness of Floseal, a thrombin-based hemostatic matrix, in total knee arthroplasty (TKA) in minimizing blood loss and transfusion requirements remains a topic of debate. This meta-analysis aims to evaluate the up-to-date randomized controlled trials (RCTs) on the efficacy and safety of Floseal in TKA. A comprehensive search was conducted in electronic databases to identify relevant RCTs. The methodological quality of the included studies was assessed, and data extraction was performed. The pooled effect sizes were calculated using standardized mean difference (SMD) or odds ratios (OR) with 95% confidence intervals (CIs). Eight studies involving 904 patients were included in the meta-analysis. The use of a thrombin-based hemostatic agent significantly reduced hemoglobin decline (SMD = −0.49, 95% CI: −0.92 to −0.07) and the risk of allogenic transfusion (OR = 0.45, 95% CI: 0.25 to 0.81) but showed no significant difference in the volume of drainage or total blood loss. Funnel plots showed no evidence of publication bias. This meta-analysis provides robust evidence supporting the effectiveness of Floseal in reducing hemoglobin decline and transfusion in TKA. Further well-designed RCTs with longer follow-up periods are warranted to assess long-term efficacy and safety. Full article
(This article belongs to the Special Issue Knee Arthroplasty: Therapeutic and Management Strategies)
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14 pages, 5143 KiB  
Review
Silk Fibroin-Based Biomaterials for Hemostatic Applications
by Md. Tipu Sultan, Heesun Hong, Ok Joo Lee, Olatunji Ajiteru, Young Jin Lee, Ji Seung Lee, Hanna Lee, Soon Hee Kim and Chan Hum Park
Biomolecules 2022, 12(5), 660; https://doi.org/10.3390/biom12050660 - 30 Apr 2022
Cited by 39 | Viewed by 7599
Abstract
Hemostasis plays an essential role in all surgical procedures. Uncontrolled hemorrhage is the primary cause of death during surgeries, and effective blood loss control can significantly reduce mortality. For modern surgeons to select the right agent at the right time, they must understand [...] Read more.
Hemostasis plays an essential role in all surgical procedures. Uncontrolled hemorrhage is the primary cause of death during surgeries, and effective blood loss control can significantly reduce mortality. For modern surgeons to select the right agent at the right time, they must understand the mechanisms of action, the effectiveness, and the possible adverse effects of each agent. Over the past decade, various hemostatic agents have grown intensely. These agents vary from absorbable topical hemostats, including collagen, gelatins, microfibrillar, and regenerated oxidized cellulose, to biologically active topical hemostats such as thrombin, biological adhesives, and other combined agents. Commercially available products have since expanded to include topical hemostats, surgical sealants, and adhesives. Silk is a natural protein consisting of fibroin and sericin. Silk fibroin (SF), derived from silkworm Bombyx mori, is a fibrous protein that has been used mostly in fashion textiles and surgical sutures. Additionally, SF has been widely applied as a potential biomaterial in several biomedical and biotechnological fields. Furthermore, SF has been employed as a hemostatic agent in several studies. In this review, we summarize the several morphologic forms of SF and the latest technological advances on the use of SF-based hemostatic agents. Full article
(This article belongs to the Special Issue 10th Anniversary of Biomolecules—Advances in Biodegradable Biomaterials)
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