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Keywords = thioaliphatic acid monolayer

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13 pages, 666 KiB  
Article
Surface Plasmon Resonance Based Biosensors for Exploring the Influence of Alkaloids on Aggregation of Amyloid-β Peptide
by Bartłomiej Emil Kraziński, Jerzy Radecki and Hanna Radecka
Sensors 2011, 11(4), 4030-4042; https://doi.org/10.3390/s110404030 - 6 Apr 2011
Cited by 23 | Viewed by 10051
Abstract
The main objective of the presented study was the development of a simple analytical tool for exploring the influence of naturally occurring compounds on the aggregation of amyloid-β peptide (Aβ40) in order to find potential anti-neurodegenerative drugs. The gold discs used [...] Read more.
The main objective of the presented study was the development of a simple analytical tool for exploring the influence of naturally occurring compounds on the aggregation of amyloid-β peptide (Aβ40) in order to find potential anti-neurodegenerative drugs. The gold discs used for surface plasmon resonance (SPR) measurements were modified with thioaliphatic acid. The surface functionalized with carboxylic groups was used for covalent attaching of Aβ40 probe by creation of amide bonds in the presence of EDC/NHS. The modified SPR gold discs were used for exploring the Aβ40 aggregation process in the presence of selected alkaloids: arecoline hydrobromide, pseudopelletierine hydrochloride, trigonelline hydrochloride and α-lobeline hydrochloride. The obtained results were discussed with other parameters which govern the phenomenon studied such as lipophilicity/ hydrophilicy and Aβ40-alkaloid association constants. Full article
(This article belongs to the Special Issue Bioinspired Sensor Systems)
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