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Search Results (2)

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Keywords = sterile neutrophilic dermatitis

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7 pages, 690 KiB  
Article
The Use of the Nitroblue Tetrazolium Test in Blood Granulocytes for Discriminating Bacterial and Non-Bacterial Neutrophilic Dermatitis
by Marina García, Icíar Martínez-Flórez, Laia Solano-Gallego, Nuria García and Laura Ordeix
Vet. Sci. 2024, 11(12), 634; https://doi.org/10.3390/vetsci11120634 - 7 Dec 2024
Viewed by 1876
Abstract
This study aimed to evaluate differences in the production of reactive oxygen species (ROS) by peripheral blood neutrophils in healthy dogs, dogs with superficial pyoderma, and dogs with sterile neutrophilic dermatitis using the nitroblue tetrazolium (NBT) reduction test. Additionally, the study assessed the [...] Read more.
This study aimed to evaluate differences in the production of reactive oxygen species (ROS) by peripheral blood neutrophils in healthy dogs, dogs with superficial pyoderma, and dogs with sterile neutrophilic dermatitis using the nitroblue tetrazolium (NBT) reduction test. Additionally, the study assessed the potential of the NBT reduction test as a diagnostic tool to differentiate between these clinical conditions. A total of 28 dogs were divided into three groups: healthy (n = 10), superficial pyoderma (n = 10), and sterile neutrophilic dermatitis (n = 8). The results showed significantly higher neutrophil activation in dogs with sterile neutrophilic dermatitis (19 ± 10%) compared with healthy dogs (7.3 ± 5%) (p < 0.01) and dogs with superficial pyoderma (10 ± 2.8%) (p < 0.05). Dogs with sterile neutrophilic dermatitis and a high positive result for Leishmania spp. antibodies (n = 3) exhibited even higher NBT reduction rates (30 ± 4.6%) compared with seronegative dogs with sterile neutrophilic dermatitis (n = 5) (13 ± 5.3%) (p < 0.05). These findings suggest that the NBT reduction test could be useful for detecting systemic neutrophil activation in sterile neutrophilic dermatitis, especially when associated with Leishmania infection. However, no significant differences were observed between healthy dogs and those with superficial pyoderma, indicating that the test may not be effective in detecting systemic neutrophil activation in superficial bacterial infections. Full article
(This article belongs to the Section Veterinary Biomedical Sciences)
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12 pages, 2557 KiB  
Review
Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis
by Morgan Sussman, Anthony Napodano, Simo Huang, Abhirup Are, Sylvia Hsu and Kiran Motaparthi
Medicina 2021, 57(10), 1004; https://doi.org/10.3390/medicina57101004 - 23 Sep 2021
Cited by 31 | Viewed by 9666
Abstract
The similarity between pustular psoriasis (PP) and acute generalized exanthematous pustulosis (AGEP) poses problems in the diagnosis and treatment of these two conditions. Significant clinical and histopathologic overlap exists between PP and AGEP. PP is an inflammatory disorder that has numerous clinical subtypes, [...] Read more.
The similarity between pustular psoriasis (PP) and acute generalized exanthematous pustulosis (AGEP) poses problems in the diagnosis and treatment of these two conditions. Significant clinical and histopathologic overlap exists between PP and AGEP. PP is an inflammatory disorder that has numerous clinical subtypes, but all with sterile pustules composed of neutrophils. AGEP is a severe cutaneous adverse reaction that is also characterized by non-follicular sterile pustules. Clinical features that suggest a diagnosis of PP over AGEP include a history of psoriasis and the presence of scaling plaques. Histologically, eosinophilic spongiosis, vacuolar interface dermatitis, and dermal eosinophilia favor a diagnosis of AGEP over PP. Importantly, PP and AGEP vary in clinical course and treatment. PP treatment involves topical steroids, oral retinoids, and systemic immunosuppressants. Newer therapies targeting IL-36, IL-23, IL-1, and PDE-4 have been investigated. The removal of the offending agent is a crucial part of the treatment of AGEP. Full article
(This article belongs to the Special Issue Updates to the Diagnosis and Medical Management of Vesiculobullous Disorders)
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