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Search Results (4)

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Keywords = staggered herringbone micromixer (SHM)

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22 pages, 3509 KB  
Article
Staggered Herringbone Microfluid Device for the Manufacturing of Chitosan/TPP Nanoparticles: Systematic Optimization and Preliminary Biological Evaluation
by Enrica Chiesa, Antonietta Greco, Federica Riva, Elena Maria Tosca, Rossella Dorati, Silvia Pisani, Tiziana Modena, Bice Conti and Ida Genta
Int. J. Mol. Sci. 2019, 20(24), 6212; https://doi.org/10.3390/ijms20246212 - 9 Dec 2019
Cited by 32 | Viewed by 6203
Abstract
Chitosan nanoparticles (CS NPs) showed promising results in drug, vaccine and gene delivery for the treatment of various diseases. The considerable attention towards CS was owning to its outstanding biological properties, however, the main challenge in the application of CS NPs was faced [...] Read more.
Chitosan nanoparticles (CS NPs) showed promising results in drug, vaccine and gene delivery for the treatment of various diseases. The considerable attention towards CS was owning to its outstanding biological properties, however, the main challenge in the application of CS NPs was faced during their size-controlled synthesis. Herein, ionic gelation reaction between CS and sodium tripolyphosphate (TPP), a widely used and safe CS cross-linker for biomedical application, was exploited by a microfluidic approach based on a staggered herringbone micromixer (SHM) for the synthesis of TPP cross-linked CS NPs (CS/TPP NPs). Screening design of experiments was applied to systematically evaluate the main process and formulative factors affecting CS/TPP NPs physical properties (mean size and size distribution). Effectiveness of the SHM-assisted manufacturing process was confirmed by the preliminary evaluation of the biological performance of the optimized CS/TPP NPs that were internalized in the cytosol of human mesenchymal stem cells through clathrin-mediated mechanism. Curcumin, selected as a challenging model drug, was successfully loaded into CS/TPP NPs (EE% > 70%) and slowly released up to 48 h via the diffusion mechanism. Finally, the comparison with the conventional bulk mixing method corroborated the efficacy of the microfluidics-assisted method due to the precise control of mixing at microscales. Full article
(This article belongs to the Special Issue Chitosan Functionalizations, Formulations and Composites)
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14 pages, 3976 KB  
Article
Design Optimization for a Microfluidic Crossflow Filtration System Incorporating a Micromixer
by Seon Yeop Jung, Jo Eun Park, Tae Gon Kang and Kyung Hyun Ahn
Micromachines 2019, 10(12), 836; https://doi.org/10.3390/mi10120836 - 30 Nov 2019
Cited by 15 | Viewed by 4898
Abstract
In this study, we report on a numerical study on design optimization for a microfluidic crossflow filtration system incorporated with the staggered herringbone micromixer (SHM). Computational fluid dynamics (CFD) and the Taguchi method were employed to find out an optimal set of design [...] Read more.
In this study, we report on a numerical study on design optimization for a microfluidic crossflow filtration system incorporated with the staggered herringbone micromixer (SHM). Computational fluid dynamics (CFD) and the Taguchi method were employed to find out an optimal set of design parameters, mitigating fouling in the filtration system. The flow and the mass transfer characteristics in a reference SHM model and a plain rectangular microchannel were numerically investigated in detail. Downwelling flows in the SHM model lead to backtransport of foulants from the permeable wall, which slows down the development of the concentration boundary layer in the filtration system. Four design parameters — the number of grooves, the groove depth, the interspace between two neighboring grooves, and the interspace between half mixing periods — were chosen to construct a set of numerical experiments using an orthogonal array L 9 ( 3 4 ) from the Taguchi method. The Analysis of Variance (ANOVA) using the evaluated signal-to-noise (SN) ratios enabled us to identify the contribution of each design parameter on the performance. The proposed optimal SHM model indeed showed the lowest growth rate of the wall concentration compared to other SHM models. Full article
(This article belongs to the Special Issue Optimization of Microfluidic Devices)
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15 pages, 6499 KB  
Article
Optimized Simulation and Validation of Particle Advection in Asymmetric Staggered Herringbone Type Micromixers
by Eszter L. Tóth, Eszter G. Holczer, Kristóf Iván and Péter Fürjes
Micromachines 2015, 6(1), 136-150; https://doi.org/10.3390/mi6010136 - 30 Dec 2014
Cited by 30 | Viewed by 11001
Abstract
This paper presents and compares two different strategies in the numerical simulation of passive microfluidic mixers based on chaotic advection. In addition to flow velocity field calculations, concentration distributions of molecules and trajectories of microscale particles were determined and compared to evaluate the [...] Read more.
This paper presents and compares two different strategies in the numerical simulation of passive microfluidic mixers based on chaotic advection. In addition to flow velocity field calculations, concentration distributions of molecules and trajectories of microscale particles were determined and compared to evaluate the performance of the applied modeling approaches in the proposed geometries. A staggered herringbone type micromixer (SHM) was selected and studied in order to demonstrate finite element modeling issues. The selected microstructures were fabricated by a soft lithography technique, utilizing multilayer SU-8 epoxy-based photoresist as a molding replica for polydimethylsiloxane (PDMS) casting. The mixing processes in the microfluidic systems were characterized by applying molecular and particle (cell) solutions and adequate microscopic visualization techniques. We proved that modeling of the molecular concentration field is more costly, in regards to computational time, than the particle trajectory based method. However, both approaches showed adequate qualitative agreement with the experimental results. Full article
(This article belongs to the Special Issue Micromixer & Micromixing)
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15 pages, 2437 KB  
Article
Evaluation of Floor-grooved Micromixers using Concentration-channel Length Profiles
by Yan Du, Zhiyi Zhang, ChaeHo Yim, Min Lin and Xudong Cao
Micromachines 2010, 1(1), 19-33; https://doi.org/10.3390/mi1010019 - 17 May 2010
Cited by 38 | Viewed by 8157
Abstract
We evaluated the dynamic micromixing performances in slanted groove micromixers (SGM) and staggered herringbone micromixers (SHM) and quantitatively compared their differences using concentration vs. channel length profiles obtained from numerical stimulations. It is found that faster and finer mixing took place in the [...] Read more.
We evaluated the dynamic micromixing performances in slanted groove micromixers (SGM) and staggered herringbone micromixers (SHM) and quantitatively compared their differences using concentration vs. channel length profiles obtained from numerical stimulations. It is found that faster and finer mixing took place in the SHM and the chaotic mixing was more effective at locations closer to the grooves; in comparison, slower and coarser mixing occurred throughout the whole channel of the SGM. Subsequently, the concentration profile-based characterization method was demonstrated in hybrid floor-grooved micromixers to study the interaction of SGM and SHM. Full article
(This article belongs to the Special Issue Micromixers)
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