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Keywords = spergulagenin A

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Article
New Triterpenoids and Anti-Inflammatory Constituents from Glinus oppositifolius
by Jih-Jung Chen, Chang-Syun Yang, Yu-Hui Chen, Che-Yi Chao, Yu-Chang Chen and Yeuh-Hsiung Kuo
Molecules 2023, 28(7), 2903; https://doi.org/10.3390/molecules28072903 - 23 Mar 2023
Cited by 9 | Viewed by 3745
Abstract
Three new triterpenoids—spergulagenin B (1), spergulagenin C (2), and spergulagenin D (3)—were isolated from the aerial part of Glinus oppositifolius, along with 17 known compounds (420). The structures of these new compounds [...] Read more.
Three new triterpenoids—spergulagenin B (1), spergulagenin C (2), and spergulagenin D (3)—were isolated from the aerial part of Glinus oppositifolius, along with 17 known compounds (420). The structures of these new compounds were identified by spectroscopic and MS analyses. Compounds 3, 5, 19, and 20 were evaluated for inhibition of nitric oxide production in LPS-stimulated RAW 264.7 cells with IC50 values of 17.03, 18.21, 16.30, and 12.64 μM, respectively. Compounds 3, 5, and 20 exhibited inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 cells with IC50 values of 18.35 ± 1.34, 17.56 ± 1.41, and 14.27 ± 1.29 μM, respectively. Full article
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