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Keywords = small nucleolar derived RNA (sdRNA)

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27 pages, 2912 KiB  
Review
Small Nucleolar Derived RNAs as Regulators of Human Cancer
by Alexander Bishop Coley, Jeffrey David DeMeis, Neil Yash Chaudhary and Glen Mark Borchert
Biomedicines 2022, 10(8), 1819; https://doi.org/10.3390/biomedicines10081819 - 28 Jul 2022
Cited by 14 | Viewed by 3387
Abstract
In the past decade, RNA fragments derived from full-length small nucleolar RNAs (snoRNAs) have been shown to be specifically excised and functional. These sno-derived RNAs (sdRNAs) have been implicated as gene regulators in a multitude of cancers, controlling a variety of genes post-transcriptionally [...] Read more.
In the past decade, RNA fragments derived from full-length small nucleolar RNAs (snoRNAs) have been shown to be specifically excised and functional. These sno-derived RNAs (sdRNAs) have been implicated as gene regulators in a multitude of cancers, controlling a variety of genes post-transcriptionally via association with the RNA-induced silencing complex (RISC). In this review, we have summarized the literature connecting sdRNAs to cancer gene regulation. SdRNAs possess miRNA-like functions and are able to fill the role of tumor-suppressing or tumor-promoting RNAs in a tissue context-dependent manner. Indeed, there are many miRNAs that are actually derived from snoRNA transcripts, meaning that they are truly sdRNAs and as such are included in this review. As sdRNAs are frequently discarded from ncRNA analyses, we emphasize that sdRNAs are functionally relevant gene regulators and likely represent an overlooked subclass of miRNAs. Based on the evidence provided by the papers reviewed here, we propose that sdRNAs deserve more extensive study to better understand their underlying biology and to identify previously overlooked biomarkers and therapeutic targets for a multitude of human cancers. Full article
(This article belongs to the Special Issue microRNAs in Health and Disease)
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