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Keywords = renal staminal cells

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13 pages, 1049 KiB  
Review
Stem Cells in Kidney Ischemia: From Inflammation and Fibrosis to Renal Tissue Regeneration
by Rosario Cianci, Mariadelina Simeoni, Eleonora Cianci, Oriana De Marco, Antonio Pisani, Claudio Ferri and Antonietta Gigante
Int. J. Mol. Sci. 2023, 24(5), 4631; https://doi.org/10.3390/ijms24054631 - 27 Feb 2023
Cited by 10 | Viewed by 4079
Abstract
Ischemic nephropathy consists of progressive renal function loss due to renal hypoxia, inflammation, microvascular rarefaction, and fibrosis. We provide a literature review focused on kidney hypoperfusion-dependent inflammation and its influence on renal tissue’s ability to self-regenerate. Moreover, an overview of the advances in [...] Read more.
Ischemic nephropathy consists of progressive renal function loss due to renal hypoxia, inflammation, microvascular rarefaction, and fibrosis. We provide a literature review focused on kidney hypoperfusion-dependent inflammation and its influence on renal tissue’s ability to self-regenerate. Moreover, an overview of the advances in regenerative therapy with mesenchymal stem cell (MSC) infusion is provided. Based on our search, we can point out the following conclusions: 1. endovascular reperfusion is the gold-standard therapy for RAS, but its success mostly depends on treatment timeliness and a preserved downstream vascular bed; 2. anti-RAAS drugs, SGLT2 inhibitors, and/or anti-endothelin agents are especially recommended for patients with renal ischemia who are not eligible for endovascular reperfusion for slowing renal damage progression; 3. TGF-β, MCP-1, VEGF, and NGAL assays, along with BOLD MRI, should be extended in clinical practice and applied to a pre- and post-revascularization protocols; 4. MSC infusion appears effective in renal regeneration and could represent a revolutionary treatment for patients with fibrotic evolution of renal ischemia. Full article
(This article belongs to the Special Issue Stem Cells in Health and Disease)
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5 pages, 238 KiB  
Case Report
Ischemic Nephropaty: The Role of the Renal Artery Stenosis Revascularization on Renal Stem Cells
by Rosario Cianci, Adolfo Marco Perrotta, Antonietta Gigante, Federica Errigo, Claudio Ferri, Eleonora Cianci, Mariadelina Simeoni, Sandro Mazzaferro and Silvia Lai
Medicina 2021, 57(9), 944; https://doi.org/10.3390/medicina57090944 - 8 Sep 2021
Cited by 4 | Viewed by 2175
Abstract
We report the case of a 65-year-old man with acute GFR decline to 37 mL/min and uncontrolled high blood pressure. He was suspected for renovascular hypertension and underwent a renal color Doppler ultrasound scan that detected a bilateral atherosclerotic renal artery stenosis. A [...] Read more.
We report the case of a 65-year-old man with acute GFR decline to 37 mL/min and uncontrolled high blood pressure. He was suspected for renovascular hypertension and underwent a renal color Doppler ultrasound scan that detected a bilateral atherosclerotic renal artery stenosis. A digital selective angiography by percutaneous transluminal angioplasty and stenting (PTRAs) was successfully performed. Blood pressure rapidly normalized, GFR increased within a few days, and proteinuria disappeared thereafter. These clinical goals were accompanied by a significant increase of circulating renal stem cells (RSC) and a slight increase of resistive index (RI) in both kidneys. This single observation suggests the need for extensive studies aimed at evaluating the predictive power of RI and RSC in detecting post-ischemic renal repair mechanisms. Full article
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